{"id":"W2090402915","doi":"10.1111/j.1471-4159.2004.02379.x","title":"Mutations in the extracellular domains of glutamate‐gated chloride channel α3 and β subunits from ivermectin‐resistant <i>Cooperia oncophora</i> affect agonist sensitivity","year":2004,"lang":"en","type":"article","venue":"Journal of Neurochemistry","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":136,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Homomeric; Glutamate receptor; Xenopus; Biology; Chloride channel; Amino acid; Sodium channel; Protein subunit; Molecular biology; Pharmacology; Biochemistry; Receptor; Chemistry; Gene; Sodium","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001272301,0.0004180333,0.0002092559,0.0002013642,0.0001364652,0.0002484072,0.0003409362,0.0002818607,0.0008075459],"category_scores_gemma":[0.000150437,0.0001942604,0.0004218089,0.0001487885,0.0002652887,0.0001235705,0.0002969596,0.0005673311,0.0003617606],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000551277,"about_ca_system_score_gemma":0.0002184194,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001406445,"about_ca_topic_score_gemma":0.001779637,"domain_scores_codex":[0.999816,0.00002154838,0.00003329969,0.00003743218,0.00005310518,0.00003862582],"domain_scores_gemma":[0.9997433,0.00003074028,0.0001330134,0.00002260664,0.00001747586,0.00005283577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000380071,0.00001004416,0.0001970329,0.000009182249,0.000004341994,0.00005109432,0.000009303742,0.00001847861,0.9993181,0.00002548281,0.00001223397,0.0003066926],"study_design_scores_gemma":[0.00005895826,0.0002678727,0.03444676,0.00001746868,0.00006601166,0.001443245,0.0000967543,0.001558214,0.9589925,0.00004032723,0.002992597,0.00001925947],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977609,0.0001549435,0.0009804335,0.00003392645,0.00001270421,0.0000272731,0.0002606502,0.00004291733,0.0007262187],"genre_scores_gemma":[0.9966001,0.0001718781,0.001257058,0.00007575184,0.000006335236,0.00003346358,0.0006946556,0.00004568645,0.001115119],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001406445,"threshold_uncertainty_score":0.003999889,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01134979335983368,"score_gpt":0.2336106786964948,"score_spread":0.2222608853366611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}