{"id":"W2090433349","doi":"10.1016/j.celrep.2014.09.030","title":"Glutamate Acts as a Key Signal Linking Glucose Metabolism to Incretin/cAMP Action to Amplify Insulin Secretion","year":2014,"lang":"en","type":"article","venue":"Cell Reports","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":155,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Core Research for Evolutional Science and Technology; Japan Science and Technology Agency; Canadian Institutes of Health Research; Novo Nordisk Pharma; Ministry of Education, Culture, Sports, Science and Technology; MSD K.K.; Wellcome Trust; Wellcome","keywords":"Incretin; Endocrinology; Internal medicine; Insulin; Glucose homeostasis; Glutamate receptor; Carbohydrate metabolism; Biology; Secretion; Chemistry; Diabetes mellitus; Insulin resistance; Receptor; Type 2 diabetes; Medicine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0008889405,0.0002500256,0.0004715201,0.0002738458,0.0001141022,0.00006893063,0.00005682161,0.000202005,0.0005826414],"category_scores_gemma":[0.00112311,0.0002280515,0.0001106179,0.0003902367,0.00002312913,0.0001122646,0.0000732793,0.0002613736,0.0009262944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00010643,"about_ca_system_score_gemma":0.0001415667,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001126039,"about_ca_topic_score_gemma":0.000004429912,"domain_scores_codex":[0.9978805,0.0000989944,0.0005680136,0.0005398204,0.0005121272,0.0004006074],"domain_scores_gemma":[0.9982138,0.0001290067,0.0002675046,0.0005196394,0.0002145077,0.0006555449],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004235927,0.0001891219,0.003037522,0.0001504613,0.00004622697,0.0001803465,0.001022696,0.0001216008,0.9798312,0.0001443496,0.001758542,0.01309431],"study_design_scores_gemma":[0.00101036,0.0004464759,0.01574729,0.0002574534,0.0002071914,0.0002820935,0.0001520365,0.0003685117,0.6153112,0.0006525609,0.3652275,0.000337333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9614679,0.0001479648,0.003790415,0.0004643245,0.0008618212,0.000612288,0.000001834109,0.0002319359,0.03242157],"genre_scores_gemma":[0.9910166,0.00003017859,0.002218998,0.00377389,0.0007616951,0.00006699428,0.0001117109,0.00004551956,0.001974377],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.36452,"threshold_uncertainty_score":0.9998516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01553003355442329,"score_gpt":0.2610878102320468,"score_spread":0.2455577766776235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}