{"id":"W2090433719","doi":"10.1016/s0005-2736(01)00392-3","title":"Encapsulation of DNA in negatively charged liposomes and inhibition of bacterial gene expression with fluid liposome-encapsulated antisense oligonucleotides","year":2001,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - Biomembranes","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":84,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université de Montréal","funders":"","keywords":"Liposome; Oligonucleotide; DNA; Nucleic acid; Molecular biology; Antisense therapy; Plasmid; Biology; Chemistry; Biochemistry; Locked nucleic acid","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002519812,0.0003996687,0.0003592457,0.0002077274,0.0001549107,0.0003432354,0.0002636354,0.0003760671,0.0005103284],"category_scores_gemma":[0.0002701926,0.0002475322,0.000325754,0.0001453747,0.0003705547,0.0003096696,0.0003225214,0.0004319149,0.0001932933],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004774216,"about_ca_system_score_gemma":0.0002338744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006315687,"about_ca_topic_score_gemma":0.0006269765,"domain_scores_codex":[0.9998467,0.00002582657,0.00001729064,0.00003157302,0.00003490508,0.00004369043],"domain_scores_gemma":[0.999846,0.00004378204,0.00004946924,0.00001694638,0.00001657575,0.00002719567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008095307,0.00001122796,0.00002787931,0.00001719417,0.000002819779,0.0000149836,0.00001150678,0.0001252488,0.9991731,0.0001822589,0.000007503437,0.0003451423],"study_design_scores_gemma":[0.000007679783,0.00006603304,0.0001183831,0.000001205931,0.000003607312,0.00001332681,0.000002797848,0.0003361604,0.9991586,0.00001898173,0.0002712727,0.000002005668],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9927685,0.0005639379,0.005613275,0.00006732889,0.00002978688,0.00003089793,0.00008949161,0.00006634588,0.0007703259],"genre_scores_gemma":[0.994491,0.000317527,0.003242996,0.00002886052,0.000008979913,0.0000332218,0.0001237905,0.00002802635,0.00172568],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006315687,"threshold_uncertainty_score":0.003463924,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009179677258539791,"score_gpt":0.2240708437615088,"score_spread":0.214891166502969,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}