{"id":"W2090442303","doi":"10.1038/sj.onc.1206890","title":"Acidic substitution of the activation loop tyrosines in TrkA supports nerve growth factor-dependent, but not nerve growth factor-independent, differentiation and cell cycle arrest in the human neuroblastoma cell line, SY5Y","year":2003,"lang":"en","type":"article","venue":"Oncogene","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":12,"is_retracted":false,"has_abstract":false,"ca_institutions":"Robarts Clinical Trials; Hospital for Sick Children; Western University","funders":"Cancer Research Society","keywords":"Nerve growth factor; Tropomyosin receptor kinase A; Biology; Autophosphorylation; Endocrinology; Internal medicine; Low-affinity nerve growth factor receptor; Cell biology; Cancer research; Phosphorylation; Protein kinase A; Receptor; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135775,0.0003374174,0.000376386,0.0003123111,0.0001678704,0.0000622159,0.0002201605,0.0001636667,0.00004714656],"category_scores_gemma":[0.0001491673,0.0002240021,0.0001283213,0.000535704,0.0001422576,0.0002856454,0.00007549601,0.0004536212,0.000008437773],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001631223,"about_ca_system_score_gemma":0.0001489018,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008992205,"about_ca_topic_score_gemma":0.0008000549,"domain_scores_codex":[0.9972684,0.000452207,0.0005245807,0.0005101136,0.0007823175,0.0004623333],"domain_scores_gemma":[0.9988259,0.0001562649,0.0003040889,0.0004313404,0.0001394034,0.0001429777],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001800382,0.001052659,0.2132806,0.0001721885,0.0000208461,0.000137376,0.000254993,0.0000169804,0.7846079,0.0001473694,0.00001259279,0.0001164495],"study_design_scores_gemma":[0.002562788,0.000292025,0.4249189,0.00005527701,0.00003312145,0.00002773872,0.00008087158,0.00004042697,0.5717977,0.00008236366,0.000002973843,0.0001057999],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978726,0.00006967511,0.00004885637,0.000187846,0.0001628754,0.001038543,0.00006269841,0.00002538673,0.0005315327],"genre_scores_gemma":[0.9993585,0.00008306015,0.000012062,0.00007313818,0.00006196296,0.0000491536,0.00007191835,0.00004010513,0.000250148],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2128103,"threshold_uncertainty_score":0.9134541,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02213978731124976,"score_gpt":0.2660969581203184,"score_spread":0.2439571708090686,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}