{"id":"W2090446824","doi":"10.1038/ncomms6696","title":"Mutational landscape of intrahepatic cholangiocarcinoma","year":2014,"lang":"it","type":"article","venue":"Nature Communications","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":459,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Michael Smith Health Research BC","keywords":"Intrahepatic Cholangiocarcinoma; KRAS; Cancer research; PTEN; Biology; CDKN2A; ARID1A; Steatohepatitis; Gene; Mutation; Medicine; Genetics; Fatty liver; Signal transduction; Internal medicine; PI3K/AKT/mTOR pathway; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004553098,0.0002832162,0.0005938885,0.0002654108,0.0002917824,0.00003018086,0.0009990183,0.0004357815,0.0002058741],"category_scores_gemma":[0.0007607676,0.0002670876,0.0002746198,0.0006090992,0.0004107947,0.0001045227,0.0004470382,0.001406579,0.000109586],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000805227,"about_ca_system_score_gemma":0.0002156956,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007569155,"about_ca_topic_score_gemma":0.0002581367,"domain_scores_codex":[0.9980253,0.0002739945,0.0006010919,0.00031869,0.000457631,0.0003232833],"domain_scores_gemma":[0.9955178,0.0009616383,0.0003154935,0.002481673,0.0005650345,0.0001583393],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001266012,0.0007434611,0.8834931,0.0003262059,0.0009145564,0.00000572049,0.003555572,0.00001137517,0.0005008807,0.05485923,0.04815637,0.007306944],"study_design_scores_gemma":[0.001686008,0.0002628978,0.9285641,0.0003064418,0.0007174753,0.00003786818,0.0005957141,0.002722202,0.000190471,0.0003926717,0.06425513,0.0002690491],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3806364,0.3308378,0.0004531113,0.04803529,0.003172197,0.00179587,0.0004568983,0.0002488628,0.2343636],"genre_scores_gemma":[0.9932175,0.001775196,0.002305934,0.001052468,0.0005870006,0.00005073398,0.0004188318,0.00004048624,0.000551903],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6125811,"threshold_uncertainty_score":0.9999781,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974111721582855,"score_gpt":0.2949482386569521,"score_spread":0.2752071214411235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}