{"id":"W2090446824","doi":"10.1038/ncomms6696","title":"Mutational landscape of intrahepatic cholangiocarcinoma","year":2014,"lang":"it","type":"article","venue":"Nature Communications","topic":"Cholangiocarcinoma and Gallbladder Cancer Studies","field":"Medicine","cited_by":459,"is_retracted":false,"has_abstract":false,"ca_institutions":"Simon Fraser University","funders":"Canadian Institutes of Health Research; Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China; Michael Smith Health Research BC","keywords":"Intrahepatic Cholangiocarcinoma; KRAS; Cancer research; PTEN; Biology; CDKN2A; ARID1A; Steatohepatitis; Gene; Mutation; Medicine; Genetics; Fatty liver; Signal transduction; Internal medicine; PI3K/AKT/mTOR pathway; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003113315,0.0001340134,0.0001829792,0.001712703,0.0003638342,0.0006292399,0.0001689146,0.0002099774,0.003623269],"category_scores_gemma":[0.0009748191,0.0001192847,0.0001476452,0.00119063,0.0002764432,0.0002132404,0.0003767693,0.0001443543,0.0002635258],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002293951,"about_ca_system_score_gemma":0.0001383005,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001864032,"about_ca_topic_score_gemma":0.002263647,"domain_scores_codex":[0.999773,0.00006126047,0.00002173239,0.0000500427,0.00004385217,0.00005023895],"domain_scores_gemma":[0.9996065,0.000132265,0.0001108395,0.00004282353,0.00005613169,0.00005140044],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001337629,0.00004191603,0.8738002,0.0001004186,0.0001360939,0.00112013,0.0008292819,0.000266943,0.10382,0.0007926333,0.0003193106,0.01743561],"study_design_scores_gemma":[0.000006879095,0.0001235031,0.989329,0.00001390579,0.00009044733,0.002255599,0.0004348325,0.0002350979,0.005545452,0.0002697414,0.001690939,0.000004450712],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981876,0.0004684612,0.00006877899,0.00003227113,0.000001303699,0.000001972972,0.0001140909,0.000004741968,0.001120673],"genre_scores_gemma":[0.999406,0.0001708977,0.00003198103,0.00001102048,0.000003415945,0.000001822677,0.00008997797,0.000003849289,0.0002809674],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003623269,"threshold_uncertainty_score":0.01212108,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01974111721582855,"score_gpt":0.2949482386569521,"score_spread":0.2752071214411235,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}