{"id":"W2090453433","doi":"10.1016/j.ygyno.2010.10.011","title":"An open-label, single-arm Phase II study of intravenous weekly (Days 1 and 8) topotecan in combination with carboplatin (Day 1) every 21days as second-line therapy in patients with platinum-sensitive relapsed ovarian cancer","year":2010,"lang":"en","type":"article","venue":"Gynecologic Oncology","topic":"Ovarian cancer diagnosis and treatment","field":"Medicine","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Centre Hospitalier de l’Université de Montréal","funders":"GlaxoSmithKline","keywords":"Topotecan; Medicine; Carboplatin; Platinum; Phases of clinical research; Oncology; Internal medicine; Surgery; Chemotherapy; Cisplatin","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00173409,0.002554802,0.005330885,0.0009177642,0.0007876318,0.001680117,0.001971921,0.002302253,0.005149676],"category_scores_gemma":[0.001469815,0.001362563,0.002055191,0.0008474115,0.002107044,0.002210651,0.0005289125,0.006714957,0.001492579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001333065,"about_ca_system_score_gemma":0.002741698,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001692755,"about_ca_topic_score_gemma":0.004679317,"domain_scores_codex":[0.9993126,0.0002855826,0.0000281811,0.0001525161,0.0000545896,0.0001664307],"domain_scores_gemma":[0.9985837,0.0002435218,0.0001903346,0.000164812,0.00006776139,0.0007499132],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8718001,0.08508657,0.001160126,0.0003875788,0.000632645,0.00008846779,0.0001527287,0.001280643,0.009728205,0.000180027,0.001539001,0.02796402],"study_design_scores_gemma":[0.7195281,0.2756889,0.002096729,0.00001147559,0.0002030842,0.00005854476,0.0000300125,0.0006773656,0.0008209572,0.0001223105,0.0007386269,0.0000238021],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9900136,0.00149085,0.0007967592,0.0005731744,0.0003855579,0.003517283,0.001270804,0.0001766291,0.001775372],"genre_scores_gemma":[0.9832352,0.001889245,0.00246641,0.0009562109,0.0005557856,0.004585197,0.002173777,0.00007341398,0.004064739],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005330885,"threshold_uncertainty_score":0.01722735,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02503719983979952,"score_gpt":0.3150109359607031,"score_spread":0.2899737361209036,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}