{"id":"W2090462236","doi":"10.1002/path.1564","title":"Model of the early development of diffuse gastric cancer in E‐cadherin mutation carriers and its implications for patient screening","year":2004,"lang":"en","type":"article","venue":"The Journal of Pathology","topic":"Cancer-related gene regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":269,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; BC Cancer Agency","funders":"","keywords":"Cancer; CDH1; Signet ring cell carcinoma; Gastrectomy; Pathology; Germline mutation; Medicine; Helicobacter pylori; Antrum; Duodenal cancer; Internal medicine; Stomach; Gastroenterology; Adenocarcinoma; Mutation; Biology; Cadherin; Gene; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001798128,0.00004856391,0.00008870378,0.00004178769,0.00003582602,0.000001228186,0.00008046343,0.00005645656,3.67687e-7],"category_scores_gemma":[0.00003836009,0.00003266454,0.0000327023,0.0000715628,0.00004235017,0.000003591778,0.00003050035,0.00005345251,1.470209e-8],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003322239,"about_ca_system_score_gemma":0.0001723357,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000009856739,"about_ca_topic_score_gemma":0.0001118483,"domain_scores_codex":[0.9994994,0.00003896719,0.0002810593,0.00005511569,0.00005150949,0.00007390686],"domain_scores_gemma":[0.9994236,0.00001090943,0.0003394895,0.0000787946,0.0001301369,0.00001712789],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001026099,0.00001875683,0.001218711,0.000007179861,0.0000209251,1.159649e-7,0.001367823,0.1445485,0.845551,0.0000270139,0.000002539566,0.007134937],"study_design_scores_gemma":[0.002399593,0.000477477,0.2354207,0.00008039345,0.00008537989,0.0001372541,0.0003191558,0.00194645,0.7582002,0.000806088,0.00002916545,0.00009810944],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9755352,0.0008708067,0.02311295,0.0002701612,0.00003883886,0.0001522165,0.00001676492,4.457976e-7,0.000002600264],"genre_scores_gemma":[0.9975907,0.0001174429,0.002236799,0.00001652792,0.00001725755,0.000008693944,0.00000185163,0.000005755464,0.000005031245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.234202,"threshold_uncertainty_score":0.1332021,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0191829767315714,"score_gpt":0.268249263937348,"score_spread":0.2490662872057766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}