{"id":"W2090490099","doi":"10.1172/jci72829","title":"Randomized trial of the anti-FGF23 antibody KRN23 in X-linked hypophosphatemia","year":2014,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Parathyroid Disorders and Treatments","field":"Medicine","cited_by":317,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Center for Advancing Translational Sciences; National Center for Research Resources; School of Medicine, Indiana University; Yale University; National Institutes of Health; Kyowa Hakko Kirin; National Institute of Diabetes and Digestive and Kidney Diseases; McGill University; Johns Hopkins University","keywords":"Hypophosphatemia; Internal medicine; Endocrinology; Medicine; Tolerability; Placebo; PHEX; Reabsorption; Kidney; Rickets; Vitamin D and neurology; Adverse effect; Pathology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001496486,0.001253949,0.002916292,0.000308938,0.0003720485,0.0008492481,0.0008462641,0.0016409,0.00673817],"category_scores_gemma":[0.001722298,0.0005660008,0.001109685,0.0002933015,0.001129105,0.0006288427,0.0004090788,0.002551292,0.0009334072],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006191089,"about_ca_system_score_gemma":0.001362789,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009754759,"about_ca_topic_score_gemma":0.001461507,"domain_scores_codex":[0.9991859,0.0004606,0.00004692155,0.0001263552,0.00005452451,0.0001256519],"domain_scores_gemma":[0.9986594,0.0003834917,0.0002869441,0.0001133163,0.00009177672,0.0004650567],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.99119,0.00232197,0.0002227091,0.0001157602,0.0002308439,0.00001733684,0.00001213513,0.0001142002,0.0008617702,0.00004225174,0.0002129838,0.004658145],"study_design_scores_gemma":[0.8909457,0.1066931,0.001074161,0.00001343355,0.0001677515,0.0000275212,0.00001127485,0.0002906015,0.0002897713,0.00007903583,0.0003992935,0.000008548473],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9894796,0.002913395,0.0005768941,0.0005518649,0.0007512857,0.003546038,0.0006131944,0.000107449,0.001460431],"genre_scores_gemma":[0.9887439,0.001350849,0.001065785,0.0008193453,0.0005095797,0.003953389,0.0005383156,0.00001638222,0.003002602],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00673817,"threshold_uncertainty_score":0.0225414,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06984510509781217,"score_gpt":0.4148532662454616,"score_spread":0.3450081611476494,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}