{"id":"W2090503872","doi":"10.1016/j.ijpharm.2010.09.032","title":"Confocal laser scanning microscopy (CLSM) based evidence for cell permeation by mono-4-(N-6-deoxy-6-amino-β-cyclodextrin)-7-nitrobenzofuran (NBD-β-CyD)","year":2010,"lang":"en","type":"article","venue":"International Journal of Pharmaceutics","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Canadian Institutes of Health Research","keywords":"Chemistry; Biophysics; Confocal microscopy; Intracellular; Confocal; Amantadine; Fluorescence; Liposome; Cyclodextrin; Endocytosis; Permeation; Cytoplasm; Fluorescence microscope; Membrane; Biochemistry; Cell; Biology; Cell biology; Pharmacology","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002288529,0.0005083915,0.0004921882,0.0003158995,0.0003992599,0.0003683666,0.0004151865,0.0007675384,0.002709518],"category_scores_gemma":[0.0002258858,0.000245959,0.0003600197,0.0002862028,0.0005439555,0.0005023939,0.0002541772,0.0009090343,0.001272409],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004762371,"about_ca_system_score_gemma":0.0004825527,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002384168,"about_ca_topic_score_gemma":0.001281788,"domain_scores_codex":[0.9998004,0.00002651375,0.00001410664,0.00004677834,0.0000445142,0.00006780565],"domain_scores_gemma":[0.9995093,0.0002235646,0.00005741554,0.00008389592,0.0000846836,0.00004106956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007302048,0.000009904533,0.00006037737,0.0000283124,0.000002147219,0.00007441177,0.00002180295,0.0000198951,0.999047,0.000259268,0.00005250171,0.0003514234],"study_design_scores_gemma":[0.000009185568,0.00005725425,0.001833728,0.000003516596,0.000006653524,0.0003697924,0.00003210089,0.0007424911,0.9957847,0.00009581555,0.00106021,0.000004586461],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9194417,0.00277684,0.05884775,0.001138866,0.0001504505,0.0001182714,0.001897824,0.000579442,0.01504878],"genre_scores_gemma":[0.97629,0.001174373,0.01732883,0.0002897187,0.00002549049,0.0001557128,0.0009160563,0.00008911179,0.00373063],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002709518,"threshold_uncertainty_score":0.009064198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03483324072185422,"score_gpt":0.3911020905827276,"score_spread":0.3562688498608734,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}