{"id":"W2090510040","doi":"10.1021/bm1004788","title":"High Molecular Weight Polyglycerol-Based Multivalent Mannose Conjugates","year":2010,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Mannose; Chemistry; Concanavalin A; Conjugate; Isothermal titration calorimetry; Ligand (biochemistry); Binding constant; Binding site; Biochemistry; Stereochemistry; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008349381,0.0003054299,0.000139041,0.0001322389,0.00007811252,0.0002181715,0.0001382573,0.0001954036,0.0004217353],"category_scores_gemma":[0.00009041514,0.00007306661,0.0001303291,0.0001535072,0.0001238086,0.0001888034,0.0002029601,0.0002751464,0.0001892513],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002022902,"about_ca_system_score_gemma":0.00009076647,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002608847,"about_ca_topic_score_gemma":0.0003487523,"domain_scores_codex":[0.999911,0.00001674319,0.000006946517,0.00001561832,0.00002823526,0.00002156206],"domain_scores_gemma":[0.9999453,0.00000644283,0.00001824889,0.000005959757,0.00000874601,0.00001532068],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001701448,0.00000782431,0.0001171979,0.00001369124,0.000003262286,0.00002822769,0.0000070921,0.0001175136,0.9980081,0.00006785402,0.000008707025,0.001603605],"study_design_scores_gemma":[0.000002020367,0.0001463885,0.0007573313,0.000001696754,0.000007894406,0.00009749587,0.000005760236,0.0003634301,0.9972907,0.00002327578,0.001300799,0.000003336727],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9913206,0.0009089023,0.006786408,0.00004201175,0.00001050112,0.00002831294,0.00006991833,0.00003952989,0.0007938069],"genre_scores_gemma":[0.9902082,0.0006643192,0.007539366,0.00003773835,0.000006306958,0.00001826001,0.0001458943,0.00001552919,0.001364441],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004217353,"threshold_uncertainty_score":0.001467645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004325955209067984,"score_gpt":0.228782955484724,"score_spread":0.2244570002756561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}