{"id":"W2090510040","doi":"10.1021/bm1004788","title":"High Molecular Weight Polyglycerol-Based Multivalent Mannose Conjugates","year":2010,"lang":"en","type":"article","venue":"Biomacromolecules","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":22,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research","keywords":"Mannose; Chemistry; Concanavalin A; Conjugate; Isothermal titration calorimetry; Ligand (biochemistry); Binding constant; Binding site; Biochemistry; Stereochemistry; In vitro; Receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001106942,0.0003302003,0.0002080883,0.0000978939,0.000110393,0.00006835931,0.000451915,0.0002881127,0.0001631137],"category_scores_gemma":[0.00006123065,0.0003053245,0.0002073689,0.0001104044,0.0002199092,0.000005810734,0.00014067,0.0001617762,0.0001694333],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008362043,"about_ca_system_score_gemma":0.00009219084,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001036539,"about_ca_topic_score_gemma":0.00007586724,"domain_scores_codex":[0.9984012,0.00005928088,0.0002853567,0.000606104,0.0002099715,0.0004380509],"domain_scores_gemma":[0.9988681,0.00001249845,0.0001036593,0.0006890784,0.0001457712,0.0001808986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001395846,0.0001431645,0.0008353613,0.00001440626,0.00007665261,0.00007929431,0.000009857815,0.00001233742,0.9950047,0.0004412722,0.001785641,0.001457788],"study_design_scores_gemma":[0.0009038103,0.0003420631,0.001822471,0.00001571705,0.00002896472,0.00003244183,0.00001396235,0.00007388412,0.9811992,0.0001541761,0.01501078,0.000402503],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959708,0.000537561,0.001329729,0.0004392863,0.0006552998,0.0002132741,0.00009298383,0.00005363834,0.0007074014],"genre_scores_gemma":[0.9949767,0.00004274504,0.003005344,0.0008839824,0.0002600346,0.00004495255,0.0003474838,0.00005274542,0.0003860039],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01380542,"threshold_uncertainty_score":0.9999399,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004325955209067984,"score_gpt":0.228782955484724,"score_spread":0.2244570002756561,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}