{"id":"W2090510390","doi":"10.1074/jbc.m403106200","title":"Carrageenan-induced Paw Edema in Rat Elicits a Predominant Prostaglandin E2 (PGE2) Response in the Central Nervous System Associated with the Induction of Microsomal PGE2 Synthase-1","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Inflammatory mediators and NSAID effects","field":"Medicine","cited_by":269,"is_retracted":false,"has_abstract":true,"ca_institutions":"Merck Canada Inc. (Canada)","funders":"Max-Planck-Gesellschaft","keywords":"Prostaglandin E2; Prostanoid; Central nervous system; Inflammation; Endocrinology; Spinal cord; Prostaglandin; Cerebrospinal fluid; Internal medicine; Eicosanoid; Prostaglandin D2; Prostaglandin E; Chemistry; Hyperalgesia; Cyclooxygenase; Thromboxane B2; Medicine; Nociception; Biochemistry; Enzyme; Arachidonic acid; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001672931,0.001106738,0.0007884123,0.0006457185,0.0001982435,0.0003029916,0.0001211335,0.0004011937,0.001572124],"category_scores_gemma":[0.0001614055,0.0002743744,0.0004596777,0.0003941574,0.0003491166,0.0004307427,0.0002031564,0.000887303,0.0003774385],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003411711,"about_ca_system_score_gemma":0.0002894977,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006422896,"about_ca_topic_score_gemma":0.001563614,"domain_scores_codex":[0.9998134,0.00002040396,0.00001101646,0.00004036699,0.00005396469,0.00006091026],"domain_scores_gemma":[0.99979,0.00001488651,0.00007558507,0.00001714611,0.00002547338,0.00007686202],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002429391,0.00003590533,0.0001452989,0.00005308432,0.000005795693,0.00005669706,0.00001090989,0.0000158894,0.9986944,0.00002014193,0.00001096484,0.0007079709],"study_design_scores_gemma":[0.00003439889,0.002922113,0.02803625,0.00002241236,0.00005804411,0.00053495,0.00006054017,0.0003807757,0.9670031,0.000113003,0.0008177237,0.0000166305],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.986211,0.008164047,0.00366743,0.00007724427,0.00006726342,0.00009460096,0.0005931523,0.0001301059,0.0009952234],"genre_scores_gemma":[0.9808466,0.006763294,0.006746584,0.0001233925,0.00007313903,0.0001566904,0.001068459,0.00001980511,0.004202059],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001572124,"threshold_uncertainty_score":0.005259335,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01508549443321569,"score_gpt":0.2384764029854033,"score_spread":0.2233909085521876,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}