{"id":"W2090534810","doi":"10.1016/j.bpj.2014.11.2825","title":"Global Contacts Direct Hydophobic Collapse in Protein Folding","year":2015,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children; University of Toronto","funders":"","keywords":"Native state; Protein folding; Helix (gastropod); Protein structure; Folding (DSP implementation); Context (archaeology); Colicin; Crystallography; Molecular dynamics; Chemistry; Biophysics; Contact order; Computational biology; Biology; Biochemistry; Computational chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001783226,0.000234717,0.0004188031,0.0001503432,0.0007821337,0.000773675,0.0002710352,0.0004128361,0.003815353],"category_scores_gemma":[0.000533325,0.0003499528,0.0001787583,0.0001339682,0.0006992146,0.0007943711,0.001168514,0.0008459126,0.0008666938],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003545004,"about_ca_system_score_gemma":0.0002052714,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003209999,"about_ca_topic_score_gemma":0.0005491339,"domain_scores_codex":[0.9998666,0.00001750217,0.000005296965,0.0000204494,0.00003818503,0.00005206314],"domain_scores_gemma":[0.9997242,0.00008232953,0.00002730691,0.00003851832,0.00001998415,0.0001075809],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0009190604,0.0001435782,0.003514927,0.0001598098,0.00005150834,0.001054077,0.0003275927,0.005742493,0.96398,0.01016385,0.001074821,0.01286824],"study_design_scores_gemma":[0.0001775598,0.0006368358,0.02033021,0.00003161247,0.00004632741,0.001505938,0.0008885019,0.04409323,0.9122527,0.0140942,0.005869182,0.00007365922],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9923885,0.0002493803,0.003901124,0.0001172574,0.00002316896,0.00001660818,0.00004026203,0.0000897603,0.003173888],"genre_scores_gemma":[0.9992955,0.0000465691,0.0001741179,0.00002161373,0.000003543238,0.00000340368,0.00002138913,0.00001125594,0.0004226632],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003815353,"threshold_uncertainty_score":0.01276362,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.010064383137205,"score_gpt":0.252791432205508,"score_spread":0.242727049068303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}