{"id":"W2090541084","doi":"10.1002/jcp.21924","title":"p38 MAPK activity is stimulated by vascular endothelial growth factor receptor 2 activation and is essential for shear stress‐induced angiogenesis","year":2009,"lang":"en","type":"article","venue":"Journal of Cellular Physiology","topic":"Angiogenesis and VEGF in Cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"York University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Phosphorylation; Angiogenesis; p38 mitogen-activated protein kinases; Prazosin; Shear stress; Endocrinology; Internal medicine; Stimulation; Vascular endothelial growth factor; MAPK/ERK pathway; Chemistry; Biology; Cell biology; Receptor; Medicine; Materials science; VEGF receptors; Antagonist","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001196363,0.0002333684,0.000379742,0.00007188371,0.0001049446,0.00002261203,0.0001734938,0.00031197,0.00009543314],"category_scores_gemma":[0.0000487687,0.0002039515,0.0003945178,0.00007565342,0.00005154446,0.00002129177,0.00003502287,0.0001018516,0.000001823066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002723321,"about_ca_system_score_gemma":0.0000832044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000161928,"about_ca_topic_score_gemma":3.906628e-7,"domain_scores_codex":[0.9988003,0.0000987991,0.0003196878,0.0003350624,0.0001669886,0.0002791586],"domain_scores_gemma":[0.9989923,0.0000338566,0.0003757854,0.0001990122,0.000282517,0.000116506],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006642141,0.0001584353,0.0001237436,0.00002492043,0.0003007561,5.593444e-7,0.00006880782,0.00001559864,0.99163,0.00000549304,0.004231726,0.002775735],"study_design_scores_gemma":[0.001297678,0.001133095,0.003415414,0.00001747584,0.00008142553,0.000003289152,0.00002052489,0.00009689587,0.9870841,0.00007834705,0.006554518,0.0002172484],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9918213,0.0009737188,0.00620782,0.0003745528,0.0002168582,0.0001978035,0.0001944203,0.000005155064,0.000008384397],"genre_scores_gemma":[0.9973422,0.0007436586,0.0003260032,0.000479884,0.0009230463,0.000004973946,0.0000746604,0.00002788213,0.00007768066],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005881817,"threshold_uncertainty_score":0.8316901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01026958645849739,"score_gpt":0.2506798306283473,"score_spread":0.2404102441698499,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}