{"id":"W2090543305","doi":"10.1039/c3mb70219g","title":"Chemical and biosynthetic evolution of the antimycin-type depsipeptides","year":2013,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Depsipeptide; Polyketide; Nonribosomal peptide; Biology; Gene cluster; Chemistry; Computational biology; Biochemistry; Enzyme; Stereochemistry; Gene; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001863037,0.0002010007,0.0001600324,0.0003527729,0.0001272267,0.0004292702,0.0001738771,0.0001927622,0.0003357868],"category_scores_gemma":[0.0002900627,0.0001436603,0.0001693026,0.0004156703,0.0001443632,0.000266832,0.0002260142,0.0004533629,0.0001903097],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003105187,"about_ca_system_score_gemma":0.0002435596,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004044715,"about_ca_topic_score_gemma":0.0006253526,"domain_scores_codex":[0.9998541,0.00003556284,0.00001558164,0.00003203213,0.00004356851,0.00001908888],"domain_scores_gemma":[0.9998412,0.00003113206,0.00005555477,0.00002189729,0.00002533405,0.00002480598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008985474,0.00002013029,0.0009347429,0.00002636721,0.000004965675,0.00007416916,0.00002227856,0.0006836642,0.9910083,0.0004233205,0.00001572489,0.006696444],"study_design_scores_gemma":[0.000009101244,0.0004705396,0.01012792,0.000009429922,0.00002854044,0.000480256,0.00007691096,0.003388632,0.9800844,0.0003238344,0.00499008,0.00001038988],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902077,0.0008375518,0.005927903,0.00006797586,0.000009425105,0.00004633403,0.0004136119,0.00003237297,0.002457002],"genre_scores_gemma":[0.9748674,0.001370495,0.02144025,0.00005661119,0.00001006763,0.00003698069,0.0007140032,0.00003320528,0.001471025],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0004292702,"threshold_uncertainty_score":0.002253056,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004968254770856829,"score_gpt":0.1967960155095996,"score_spread":0.1918277607387428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}