{"id":"W2090543305","doi":"10.1039/c3mb70219g","title":"Chemical and biosynthetic evolution of the antimycin-type depsipeptides","year":2013,"lang":"en","type":"article","venue":"Molecular BioSystems","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Depsipeptide; Polyketide; Nonribosomal peptide; Biology; Gene cluster; Chemistry; Computational biology; Biochemistry; Enzyme; Stereochemistry; Gene; Biosynthesis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001104312,0.0001198027,0.0002257441,0.00004881897,0.00003774101,0.00001618585,0.00009510478,0.0001075938,0.00004798473],"category_scores_gemma":[0.0001862632,0.0000676178,0.00008251306,0.0002458854,0.0001253867,0.00003007782,0.00006817714,0.00009745577,0.00002778751],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003530857,"about_ca_system_score_gemma":0.00003423886,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000262477,"about_ca_topic_score_gemma":0.000001841274,"domain_scores_codex":[0.999184,0.00005149993,0.0002212757,0.0002183865,0.000168009,0.0001568607],"domain_scores_gemma":[0.9993454,0.00001709116,0.00008565036,0.0003386059,0.0001506115,0.0000626672],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001354002,0.00003044262,0.00176272,0.0001623924,0.00003209785,0.000001903867,0.0000154867,1.058202e-7,0.9965259,0.0001735969,0.0005921336,0.0006897126],"study_design_scores_gemma":[0.0001912041,0.00004640175,0.003864732,0.000249127,0.00006131481,0.0001200942,0.00004304159,0.0000624439,0.99456,0.00004433892,0.0006707501,0.00008651885],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954873,0.001561519,0.00001024685,0.001866962,0.0001691584,0.0005468813,0.0000035103,0.00002240116,0.0003320364],"genre_scores_gemma":[0.9994028,0.00001572692,0.0002300323,0.0001205685,0.00005524951,8.900079e-7,0.00000194656,0.00001394621,0.0001588641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003915492,"threshold_uncertainty_score":0.2757374,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004968254770856829,"score_gpt":0.1967960155095996,"score_spread":0.1918277607387428,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}