{"id":"W2090562511","doi":"10.1016/j.freeradbiomed.2007.01.013","title":"Phosphorylation of the survival kinase Akt by superoxide is dependent on an ascorbate-reversible oxidation of PTEN","year":2007,"lang":"en","type":"article","venue":"Free Radical Biology and Medicine","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":55,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Biomedical Research Council; University Health Network","keywords":"PTEN; Protein kinase B; Phosphorylation; Phosphatase; PI3K/AKT/mTOR pathway; Chemistry; Cell biology; Superoxide; LY294002; Kinase; Proto-Oncogene Proteins c-akt; Cancer research; Molecular biology; Signal transduction; Biology; Biochemistry; Enzyme","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003042325,0.0004029469,0.0001926106,0.0002800801,0.0003118422,0.0003970488,0.0002781558,0.0002220566,0.001309957],"category_scores_gemma":[0.0002251028,0.0002365743,0.0004338355,0.0001955674,0.0003159519,0.0004105948,0.0003888369,0.0006494419,0.0002788353],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003683959,"about_ca_system_score_gemma":0.0002853745,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003269201,"about_ca_topic_score_gemma":0.0005089636,"domain_scores_codex":[0.999808,0.00002412167,0.00001793223,0.00003340656,0.0000577076,0.00005886334],"domain_scores_gemma":[0.999854,0.00002120425,0.0000511847,0.00002678294,0.00001732361,0.00002957745],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004743519,0.00008024462,0.000476059,0.00004958591,0.00001482987,0.0001054261,0.00002500289,0.00009075129,0.9954732,0.00150536,0.0001370249,0.001568154],"study_design_scores_gemma":[0.00004284775,0.0001516706,0.004603229,0.000004836304,0.0000166578,0.00029104,0.00001739947,0.0006886766,0.9922228,0.0003346246,0.001619679,0.000006546927],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991945,0.001209388,0.004389017,0.0003449066,0.00009563734,0.0000348212,0.0002779005,0.0001011893,0.001602172],"genre_scores_gemma":[0.9969049,0.0004772241,0.0008067797,0.00003474994,0.00001057357,0.00001742478,0.0003018832,0.00000961961,0.001436767],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001309957,"threshold_uncertainty_score":0.004382253,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01195633040365097,"score_gpt":0.2846342759580527,"score_spread":0.2726779455544017,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}