{"id":"W2090602226","doi":"10.1074/jbc.m109.098160","title":"Mutational Tuning of Galectin-3 Specificity and Biological Function","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Galectin; Intracellular; Glycoconjugate; Mutant; Biochemistry; Galactosides; Biology; Glycan; Lectin; Cell biology; Binding site; Galactoside; Glycoprotein; Galactose; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0003944754,0.0001238966,0.0003267177,0.00003189702,0.00007472584,0.00000584231,0.0001458201,0.0004955874,0.001678773],"category_scores_gemma":[0.0003652517,0.00007894415,0.0001176565,0.00008108914,0.0005031516,0.00003042467,0.00005313254,0.0007263301,0.000005526309],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001194075,"about_ca_system_score_gemma":0.00004836893,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000003847095,"about_ca_topic_score_gemma":0.000001214175,"domain_scores_codex":[0.9991125,0.00006800087,0.0004383055,0.0001688496,0.00003214373,0.0001801841],"domain_scores_gemma":[0.9990583,0.0002278335,0.0004126983,0.00008444493,0.0001790196,0.00003768548],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000375833,0.00009066342,0.04523453,0.00000838335,0.00006406057,0.000005276914,0.00001861249,6.152552e-7,0.9504334,0.0001473581,0.0001975292,0.003423776],"study_design_scores_gemma":[0.001067352,0.000894805,0.2506062,0.0000165507,0.0000283992,0.001959305,0.0002204057,0.000001459184,0.7314132,0.001562456,0.01207134,0.0001585455],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968069,0.001018193,0.0001886145,0.0001009649,0.0005063987,0.00003346396,0.00001106608,0.00001093449,0.00132342],"genre_scores_gemma":[0.9992404,0.0001269659,0.0002533773,0.00005233552,0.0002007244,0.000001386758,0.00001740627,0.000003485046,0.000103922],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2190202,"threshold_uncertainty_score":0.9992338,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02238681323374139,"score_gpt":0.2420510697425666,"score_spread":0.2196642565088252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}