{"id":"W2090602226","doi":"10.1074/jbc.m109.098160","title":"Mutational Tuning of Galectin-3 Specificity and Biological Function","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Galectins and Cancer Biology","field":"Immunology and Microbiology","cited_by":121,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Institute of General Medical Sciences","keywords":"Galectin; Intracellular; Glycoconjugate; Mutant; Biochemistry; Galactosides; Biology; Glycan; Lectin; Cell biology; Binding site; Galactoside; Glycoprotein; Galactose; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001735205,0.0004680502,0.000205929,0.0001974017,0.0001161791,0.0002964369,0.0002944985,0.0003339992,0.001129816],"category_scores_gemma":[0.0002973517,0.0001453771,0.000400312,0.0001822691,0.0003440967,0.0001378133,0.0003366662,0.0006609981,0.0003225752],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004532615,"about_ca_system_score_gemma":0.0002101821,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009521854,"about_ca_topic_score_gemma":0.0007524886,"domain_scores_codex":[0.9997359,0.0000628341,0.00003999509,0.00004185905,0.00007025002,0.00004916014],"domain_scores_gemma":[0.9998024,0.00005736056,0.00005150307,0.00003322445,0.00001792714,0.00003762629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008401978,0.00002416751,0.0001765769,0.00001209728,0.000008193249,0.00005839394,0.000008224525,0.0002483784,0.998686,0.0001110489,0.00002034025,0.0005624794],"study_design_scores_gemma":[0.0000202265,0.0001469144,0.002245465,0.000004306482,0.00002299823,0.0004763327,0.00001421867,0.001611136,0.9940806,0.00004504961,0.001323795,0.000008927785],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958295,0.0001955351,0.002513641,0.00004792937,0.00001575192,0.00002603989,0.0003583039,0.00006216131,0.0009509853],"genre_scores_gemma":[0.9968155,0.00014906,0.001957912,0.00003860425,0.000003553351,0.00001847873,0.0003172907,0.00004157334,0.0006579699],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001129816,"threshold_uncertainty_score":0.00377959,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02238681323374139,"score_gpt":0.2420510697425666,"score_spread":0.2196642565088252,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}