{"id":"W2090605523","doi":"10.1091/mbc.e09-01-0061","title":"Revisiting the Role of Cystic Fibrosis Transmembrane Conductance Regulator and Counterion Permeability in the pH Regulation of Endocytic Organelles","year":2009,"lang":"en","type":"article","venue":"Molecular Biology of the Cell","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":73,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; McGill University","funders":"Canadian Institutes of Health Research; National Institutes of Health; Johns Hopkins University","keywords":"Endosome; Endocytic cycle; Cystic fibrosis transmembrane conductance regulator; Cell biology; Biology; Proton pump; Endocytosis; Organelle; Phagosome; Intracellular; Biophysics; Biochemistry; ATPase; Cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000627803,0.0001001337,0.0002973599,0.00003927184,0.00004147269,0.000003234592,0.0002257641,0.00006212996,0.00001466789],"category_scores_gemma":[0.0004296276,0.00005101326,0.00008265298,0.0002109071,0.0005978799,0.00002157442,0.00002952475,0.0001361702,2.586085e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002402003,"about_ca_system_score_gemma":0.00004973799,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002734909,"about_ca_topic_score_gemma":0.000002757332,"domain_scores_codex":[0.998744,0.0003864146,0.0003504704,0.0001788159,0.0001880046,0.0001523048],"domain_scores_gemma":[0.9988924,0.0003415222,0.0001888629,0.0004638112,0.0000936369,0.00001980101],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002294357,0.00003633703,0.002605392,0.0002124349,0.000009810837,6.918338e-7,0.00043713,0.00005821445,0.9940204,0.0003234098,0.000001552247,0.002065195],"study_design_scores_gemma":[0.0005784489,0.0002649582,0.08317272,0.0002125507,0.00004998397,0.00002318128,0.0003978074,0.0006195692,0.910915,0.003628288,0.00009350479,0.00004398759],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920743,0.005784627,0.0001646225,0.001293583,0.00001417325,0.0004910461,0.00001432029,0.000003630247,0.0001596853],"genre_scores_gemma":[0.9992554,0.0000718271,0.0005706407,0.00005956549,0.00001477519,0.000004555757,0.00000719212,0.000005713901,0.00001029245],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0831054,"threshold_uncertainty_score":0.2202913,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0062492130181565,"score_gpt":0.260805057527085,"score_spread":0.2545558445089285,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}