{"id":"W2090627754","doi":"10.1021/bi700380a","title":"Probing DNA Polymerase−DNA Interactions:  Examining the Template Strand in Exonuclease Complexes Using 2-Aminopurine Fluorescence and Acrylamide Quenching","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Klenow fragment; Exonuclease; Coding strand; DNA polymerase; Primer (cosmetics); Exonuclease III; DNA; Polymerase; Biophysics; Base pair; DNA clamp; Fluorescence; Proofreading; Chemistry; Molecular biology; Biology; Biochemistry; Polymerase chain reaction; Reverse transcriptase; Physics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000701755,0.001122874,0.0006949982,0.0003812706,0.0004337345,0.0007750264,0.001014385,0.001372101,0.001242899],"category_scores_gemma":[0.0009103023,0.0008350755,0.000441937,0.0003761436,0.0004614946,0.001105232,0.0004645732,0.001490962,0.0005628646],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006211255,"about_ca_system_score_gemma":0.0003312919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008454588,"about_ca_topic_score_gemma":0.001073568,"domain_scores_codex":[0.999298,0.000121219,0.00003553069,0.0002348933,0.0002012555,0.0001092193],"domain_scores_gemma":[0.9992948,0.0002868634,0.0001846769,0.00004996928,0.00008417745,0.00009955838],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001673985,0.00001199244,0.0001166342,0.00003266343,0.000004928525,0.00002649212,0.00002662377,0.00005604137,0.9992715,0.00003174207,0.00000591436,0.0003988371],"study_design_scores_gemma":[0.000007487022,0.00008350748,0.00132174,0.000004101845,0.000006103856,0.0001028653,0.00002446318,0.001209251,0.9966508,0.00005479438,0.0005264687,0.000008560563],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.931196,0.002985574,0.06351689,0.0001018957,0.00003624173,0.00009895073,0.000195023,0.0002540944,0.001615427],"genre_scores_gemma":[0.9359651,0.001907966,0.05785159,0.0001784969,0.00002551096,0.0002012798,0.0005534053,0.0001413892,0.003175216],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001372101,"threshold_uncertainty_score":0.004506588,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993382159874143,"score_gpt":0.2689943166413797,"score_spread":0.2490604950426382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}