{"id":"W2090627754","doi":"10.1021/bi700380a","title":"Probing DNA Polymerase−DNA Interactions:  Examining the Template Strand in Exonuclease Complexes Using 2-Aminopurine Fluorescence and Acrylamide Quenching","year":2007,"lang":"en","type":"article","venue":"Biochemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":24,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"","keywords":"Klenow fragment; Exonuclease; Coding strand; DNA polymerase; Primer (cosmetics); Exonuclease III; DNA; Polymerase; Biophysics; Base pair; DNA clamp; Fluorescence; Proofreading; Chemistry; Molecular biology; Biology; Biochemistry; Polymerase chain reaction; Reverse transcriptase; Physics; Escherichia coli","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003748052,0.0002777898,0.0001874089,0.00004177647,0.0002204612,0.00007387459,0.0002713012,0.0001698462,0.0000257812],"category_scores_gemma":[0.0001206674,0.0002482637,0.00005666827,0.0001323171,0.000243545,0.00001670091,0.0002106644,0.0002709904,0.00000129838],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005107093,"about_ca_system_score_gemma":0.00006802634,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007913109,"about_ca_topic_score_gemma":0.00003375949,"domain_scores_codex":[0.9984489,0.00002741812,0.0003942463,0.0005284091,0.0001578488,0.0004431777],"domain_scores_gemma":[0.9992013,0.00005145164,0.0001533158,0.0004180075,0.0000391116,0.0001368022],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000965041,0.00004845238,0.004693395,0.00008332208,0.0000278781,0.00003281415,0.0001192043,0.000007529393,0.9926692,0.000003706515,0.00008339323,0.002134587],"study_design_scores_gemma":[0.0005506565,0.00002794341,0.003203334,0.0001696935,0.00002044504,0.0002410406,0.0009613698,0.0001743438,0.9938886,0.00001398527,0.000443224,0.0003053315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977752,0.0008806229,0.0001706477,0.00006279033,0.00008146303,0.000130518,0.00001736681,0.00002434003,0.0008570772],"genre_scores_gemma":[0.9982383,0.0000634964,0.0009678631,0.0001142103,0.0003089836,0.000009825231,0.00005704663,0.00003404009,0.0002062224],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001829256,"threshold_uncertainty_score":0.999997,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993382159874143,"score_gpt":0.2689943166413797,"score_spread":0.2490604950426382,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}