{"id":"W2090639347","doi":"10.1042/bj20040822","title":"Betaine rescue of an animal model with methylenetetrahydrofolate reductase deficiency","year":2004,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":78,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Montreal Children's Hospital","funders":"Canadian Institutes of Health Research; Deutsche Forschungsgemeinschaft","keywords":"Methylenetetrahydrofolate reductase; Homocystinuria; Betaine; Homocysteine; Endocrinology; Internal medicine; Methionine; Choline; Cystathionine beta synthase; Biology; Medicine; Biochemistry; Amino acid","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003433721,0.0001428604,0.0002731637,0.0001674451,0.00007344867,0.00002102678,0.0001743468,0.0001174962,0.00003684935],"category_scores_gemma":[0.00008924062,0.00009491352,0.00009935711,0.0003023735,0.0001906411,0.0001260915,0.0000373827,0.0005446082,0.00000566742],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009727319,"about_ca_system_score_gemma":0.000478374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002565553,"about_ca_topic_score_gemma":0.000001702476,"domain_scores_codex":[0.9984493,0.00002624272,0.0003251593,0.0002204572,0.0006020298,0.0003768233],"domain_scores_gemma":[0.9989654,0.00001191157,0.0000687858,0.0002504287,0.0002490686,0.0004543592],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001202225,0.00049897,0.0001769944,0.0000393792,0.00004706113,0.0002366116,0.0001017167,0.0003847918,0.9963876,0.0001124339,0.0001108503,0.0007013794],"study_design_scores_gemma":[0.003135799,0.003034387,0.0009945018,0.0001409345,0.0001020357,0.00253075,0.00009946385,0.00297751,0.9863507,0.0004561126,0.00002738698,0.000150463],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9972923,0.0007656542,0.0006024362,0.0008006104,0.00001458661,0.000112071,0.000009153844,0.00001691453,0.0003862924],"genre_scores_gemma":[0.9826621,0.0001030402,0.01691849,0.0000670862,0.0001451181,0.000001667834,0.00001273612,0.00002205968,0.0000677356],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01631606,"threshold_uncertainty_score":0.3870461,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02334887357542878,"score_gpt":0.31399530883557,"score_spread":0.2906464352601412,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}