{"id":"W2090651792","doi":"10.1016/j.addr.2005.04.002","title":"Bacterial resistance to antibiotics: Enzymatic degradation and modification","year":2005,"lang":"en","type":"review","venue":"Advanced Drug Delivery Reviews","topic":"Antibiotic Resistance in Bacteria","field":"Biochemistry, Genetics and Molecular Biology","cited_by":869,"is_retracted":false,"has_abstract":false,"ca_institutions":"McMaster University","funders":"","keywords":"Antibiotics; Efflux; Antibiotic resistance; Enzyme; Glycosylation; Chemistry; Mechanism (biology); Drug resistance; Bacteria; Microbiology; Biochemistry; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006719406,0.00168525,0.0023328,0.001692813,0.000313332,0.001075704,0.001335679,0.001663866,0.002330602],"category_scores_gemma":[0.0006133915,0.0006248993,0.0005972335,0.002130451,0.0009033095,0.001620212,0.0006247203,0.001953072,0.003740348],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000768947,"about_ca_system_score_gemma":0.0006337491,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006703978,"about_ca_topic_score_gemma":0.0008372332,"domain_scores_codex":[0.9997017,0.00003626567,0.00003533738,0.00005787252,0.000136806,0.00003195463],"domain_scores_gemma":[0.9996979,0.0001200475,0.0000497673,0.00002254507,0.00008631784,0.00002347135],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001279414,0.0001685899,0.0001276443,0.009821884,0.0000635282,0.0002857606,0.00005709525,0.0007739333,0.03249213,0.004810634,0.02399735,0.9272736],"study_design_scores_gemma":[0.00003711538,0.0002108631,0.0005134258,0.000945903,0.00009020899,0.002072746,0.00003987774,0.0003254293,0.01437373,0.002252229,0.9791049,0.00003337603],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003295912,0.9962381,0.001560975,0.000167723,0.000346657,0.000009337468,0.00001459848,0.00002727337,0.001305684],"genre_scores_gemma":[0.001457999,0.9948542,0.001238176,0.0001625298,0.0002234141,0.00002044833,0.00004088616,0.000004815377,0.001997605],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.0023328,"threshold_uncertainty_score":0.007796645,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03361755298817881,"score_gpt":0.3244485255172674,"score_spread":0.2908309725290886,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}