{"id":"W2090670914","doi":"10.1016/j.canlet.2009.01.031","title":"Induction of heat shock response by curcumin in human leukemia cells","year":2009,"lang":"en","type":"article","venue":"Cancer Letters","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Fondation Recherche Cancer et Sang; Recherches Scientifiques Luxembourg; Een Häerz fir kriibskrank Kanner; Institut national de la recherche scientifique","keywords":"Curcumin; p38 mitogen-activated protein kinases; Heat shock protein; Hsp70; Heat shock; HSF1; Heat shock factor; K562 cells; Cell biology; MAPK/ERK pathway; Transcription factor; Kinase; Protein kinase A; Biology; Hsp90; Molecular biology; Chemistry; In vitro; Biochemistry; Gene","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002426377,0.00009934029,0.0001172769,0.00007829729,0.00003194312,0.000008228617,0.0001575124,0.0001133256,0.00003192712],"category_scores_gemma":[0.00002519559,0.0001047668,0.00004085962,0.0001337073,0.00006851945,0.000004531554,0.00003034404,0.0001465702,0.000003223664],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001985949,"about_ca_system_score_gemma":0.0001195202,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002638578,"about_ca_topic_score_gemma":0.00002176188,"domain_scores_codex":[0.9990433,0.000132342,0.0001774193,0.0002598696,0.0001414509,0.0002455484],"domain_scores_gemma":[0.9996177,0.000006560396,0.00002420045,0.0002660063,0.00002783531,0.00005771738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002798754,0.00001998576,0.0004391898,0.00000873791,0.000006414013,0.000003695874,0.00005158336,0.000404331,0.9669028,0.000001133445,0.0304125,0.001469751],"study_design_scores_gemma":[0.0004659501,0.0001875774,0.002705793,0.00002214271,0.000001886419,0.00000132078,0.00001379145,0.00001439806,0.9757514,0.000003506933,0.02072621,0.0001060337],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9961752,0.0004174093,0.000222606,0.002813358,0.00005287212,0.0001972012,0.0000155428,0.00000521486,0.0001005607],"genre_scores_gemma":[0.9978879,0.00004603779,0.0000498087,0.00149858,0.00009334976,0.00003009466,0.00002431366,0.00001204296,0.0003578838],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009686291,"threshold_uncertainty_score":0.4272264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01252154024865804,"score_gpt":0.3019491521902367,"score_spread":0.2894276119415786,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}