{"id":"W2090727866","doi":"10.1016/s0168-1656(01)00428-x","title":"Design of high essential amino acid proteins: two design strategies for improving protease resistance of the nutritious MB-1 protein","year":2002,"lang":"en","type":"article","venue":"Journal of Biotechnology","topic":"Transgenic Plants and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":6,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada; Dairy Farmers of Canada","keywords":"Mutant; Protein design; Protease; Protein engineering; Amino acid; Biochemistry; Denaturation (fissile materials); Mutagenesis; Protein folding; Protein structure; Biology; Chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004107771,0.0007724974,0.0006153308,0.0002380789,0.0002288209,0.0006535143,0.0006398555,0.0007473585,0.0006876962],"category_scores_gemma":[0.0003964741,0.0003727786,0.0005094808,0.000227266,0.0003820311,0.0004589153,0.0004098602,0.001230323,0.000456806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000519837,"about_ca_system_score_gemma":0.0003157342,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003403068,"about_ca_topic_score_gemma":0.000425749,"domain_scores_codex":[0.9997267,0.0000399345,0.00003149747,0.0000665352,0.00008066237,0.00005467121],"domain_scores_gemma":[0.9998155,0.00002468404,0.00006616472,0.00001778495,0.0000321181,0.00004376617],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001531589,0.00005227324,0.0001090925,0.00007135895,0.000007987484,0.00004153258,0.00003338615,0.0005291091,0.9951499,0.0004504617,0.00005030621,0.0033515],"study_design_scores_gemma":[0.00006498486,0.0003956182,0.0002949871,0.000005219164,0.00002981504,0.0001799978,0.00002185711,0.001935907,0.9934084,0.0001160067,0.003535357,0.00001173114],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8758029,0.002166477,0.1187477,0.000564789,0.0001465377,0.0003654176,0.0002815744,0.000277364,0.001647175],"genre_scores_gemma":[0.8638189,0.001763835,0.1278429,0.0003628249,0.0000405427,0.0003109233,0.0007973581,0.0001445725,0.004918142],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007724974,"threshold_uncertainty_score":0.003771722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01497294366781079,"score_gpt":0.2304011648384096,"score_spread":0.2154282211705988,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}