{"id":"W2090753242","doi":"10.1016/j.jalz.2010.05.1305","title":"P2‐255: Ketone bodies, sodium oxybate and Alzheimer's disease: Oxidative stress and neuroprotection","year":2010,"lang":"en","type":"article","venue":"Alzheimer s & Dementia","topic":"Biochemical Acid Research Studies","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"","keywords":"Neuroprotection; Oxidative stress; Pentose phosphate pathway; Antioxidant; Oxidative phosphorylation; Ketone bodies; Chemistry; Biochemistry; Reactive oxygen species; Nicotinamide adenine dinucleotide phosphate; Trypan blue; Pharmacology; Internal medicine; Endocrinology; Biology; Medicine; Metabolism; Glycolysis; Apoptosis; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001477573,0.000251417,0.0001652885,0.00004290939,0.0002559252,0.00007112705,0.0001596815,0.0001298917,0.00003522469],"category_scores_gemma":[0.00009028985,0.0002253719,0.00005131069,0.00006048254,0.0005162412,0.00001443606,0.0005773444,0.0002746525,0.000008541672],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":9.766795e-7,"about_ca_system_score_gemma":0.00003267553,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006826873,"about_ca_topic_score_gemma":0.00009590019,"domain_scores_codex":[0.9985576,0.0000675835,0.0001888187,0.000605232,0.0002009206,0.0003798786],"domain_scores_gemma":[0.9991884,0.00001800502,0.00007750853,0.0003400985,0.0001172189,0.0002587975],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002041153,0.0001019223,0.007765147,0.00001456806,0.00470769,0.000008522964,0.0000468552,4.407806e-7,0.9696364,0.00006654293,0.002024512,0.0154233],"study_design_scores_gemma":[0.000522685,0.0002165803,0.0309475,0.00001036318,0.002248845,0.000007712583,0.00003681879,0.00003729436,0.9425115,0.0001528761,0.02297413,0.0003336951],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8469843,0.1503279,0.00008624356,0.001276433,0.0002731511,0.0005481543,0.0000996709,0.00003987364,0.0003642884],"genre_scores_gemma":[0.9969124,0.001758906,0.0006468486,0.0001933331,0.0002441889,0.00008792106,0.0001092304,0.00002979845,0.00001741343],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1499281,"threshold_uncertainty_score":0.91904,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01377833581297551,"score_gpt":0.263166928621353,"score_spread":0.2493885928083775,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}