{"id":"W2090790217","doi":"10.3389/fphar.2014.00139","title":"The glial response to intracerebrally delivered therapies for neurodegenerative disorders: is this a critical issue?","year":2014,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; National Institute for Health and Care Research","keywords":"Neuroscience; Neuropharmacology; Medicine; Deep brain stimulation; Neurodegeneration; Central nervous system; Microglia; Biology; Immunology; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006863464,0.0005402211,0.001133582,0.0003731193,0.0004728722,0.0001386151,0.001374076,0.0002335579,0.00006079733],"category_scores_gemma":[0.002283169,0.0003905726,0.0003431973,0.0007008497,0.0004957495,0.0001773727,0.0002310886,0.0007191587,0.00005886045],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001329311,"about_ca_system_score_gemma":0.0001968721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000002488447,"about_ca_topic_score_gemma":0.000002975848,"domain_scores_codex":[0.9956111,0.001431049,0.0006407117,0.00111389,0.0002692208,0.0009339895],"domain_scores_gemma":[0.9953052,0.00395797,0.0001472329,0.0003553305,0.00004038229,0.0001938267],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001183968,0.0001090209,7.020459e-7,0.001043848,0.00003279359,0.00004378219,0.0007589337,0.00002782924,0.01678379,0.0003427305,0.269975,0.7096976],"study_design_scores_gemma":[0.0004248684,0.0004587503,4.684751e-7,0.0001748085,0.0001111486,0.00001746777,0.00001896442,0.001682818,0.003537556,0.0001940885,0.9929773,0.0004017456],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0003853992,0.9551542,0.004548546,0.01085825,0.02448096,0.004074757,0.0002279491,0.0001566266,0.00011329],"genre_scores_gemma":[0.0001970565,0.9890671,0.0008486633,0.006548341,0.0005986624,0.001212651,0.000001782675,0.00009623476,0.001429478],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.7230023,"threshold_uncertainty_score":0.9998546,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03552111945372657,"score_gpt":0.3777479665083754,"score_spread":0.3422268470546489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}