{"id":"W2090790217","doi":"10.3389/fphar.2014.00139","title":"The glial response to intracerebrally delivered therapies for neurodegenerative disorders: is this a critical issue?","year":2014,"lang":"en","type":"review","venue":"Frontiers in Pharmacology","topic":"Neuroscience and Neural Engineering","field":"Neuroscience","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"Canadian Institutes of Health Research; National Institute for Health and Care Research","keywords":"Neuroscience; Neuropharmacology; Medicine; Deep brain stimulation; Neurodegeneration; Central nervous system; Microglia; Biology; Immunology; Pathology; Disease","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009192168,0.0006769797,0.001718092,0.00128407,0.0002518004,0.001275454,0.001075165,0.001847104,0.001736506],"category_scores_gemma":[0.0009277769,0.0002171569,0.0004191931,0.001303253,0.0009621672,0.001936412,0.0005712561,0.002173003,0.001882254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005536057,"about_ca_system_score_gemma":0.0009741394,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008384087,"about_ca_topic_score_gemma":0.001486906,"domain_scores_codex":[0.9997728,0.00004137472,0.00003746656,0.0000359319,0.00009449007,0.00001794825],"domain_scores_gemma":[0.9995079,0.000278086,0.00004866652,0.00001456477,0.0001251324,0.00002568138],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007182261,0.00007125574,0.0001292739,0.0208453,0.00006128346,0.0002775487,0.0001482026,0.0002769004,0.00637225,0.006196938,0.02472303,0.9408262],"study_design_scores_gemma":[0.00001824299,0.0002006294,0.0008344748,0.004434333,0.00009330259,0.002435409,0.0001958378,0.00008388656,0.001723306,0.003483706,0.9864649,0.00003204852],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0001137395,0.9981393,0.0001728723,0.0005803454,0.0002784464,0.000003085261,0.00000832409,0.000005386654,0.0006984294],"genre_scores_gemma":[0.0005232572,0.9984183,0.000180886,0.0002714425,0.0002320307,0.000004893159,0.00000836754,0.000001784974,0.0003589408],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001847104,"threshold_uncertainty_score":0.005809128,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03552111945372657,"score_gpt":0.3777479665083754,"score_spread":0.3422268470546489,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}