{"id":"W2090798921","doi":"10.1210/me.2003-0488","title":"Down-Regulation of Inositol 1,4,5-Trisphosphate Receptor in Cells Stably Expressing the Constitutively Active Angiotensin II N111G-AT1 Receptor","year":2004,"lang":"en","type":"article","venue":"Molecular Endocrinology","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Biology; Inositol trisphosphate receptor; Phospholipase C; Gq alpha subunit; Receptor; Angiotensin II; Inositol; Inositol trisphosphate; Inositol phosphate; Cell biology; Intracellular; Extracellular; Purinergic receptor; HEK 293 cells; Signal transduction; G protein; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001562044,0.0002962252,0.0003566661,0.0001273528,0.0001796086,0.00002155833,0.0003270362,0.0002506464,0.00009411894],"category_scores_gemma":[0.00008662289,0.0002566076,0.0001719626,0.0002422824,0.000320553,0.00001570735,0.0002583411,0.0002458196,0.00001468454],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007291712,"about_ca_system_score_gemma":0.0001875184,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002121756,"about_ca_topic_score_gemma":0.00003418283,"domain_scores_codex":[0.9979961,0.0002109794,0.0004647628,0.0005599922,0.0002088945,0.0005592873],"domain_scores_gemma":[0.9990143,0.0000258965,0.0002639477,0.0004482617,0.0001729806,0.00007459822],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002376908,0.0001078135,0.0000611537,0.000009635343,0.00008106678,0.00001494942,0.0002430685,0.003014323,0.9891247,0.00356287,0.0002384544,0.003304317],"study_design_scores_gemma":[0.001417192,0.0003191232,0.0002910892,0.00005283249,0.00002479327,0.00002166231,0.0002321201,0.00002357827,0.9848592,0.0004668639,0.0120234,0.000268096],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9835427,0.001175941,0.01329943,0.0005513068,0.0005551529,0.0004947183,0.0000506888,0.00002129721,0.0003087067],"genre_scores_gemma":[0.9932656,0.000184848,0.005995519,0.0002150812,0.00008621418,0.00004145705,0.00009932501,0.00003551758,0.00007644675],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01178495,"threshold_uncertainty_score":0.9999886,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007740626714789586,"score_gpt":0.2268808303743984,"score_spread":0.2191402036596088,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}