{"id":"W2090827834","doi":"10.1016/j.bbrc.2009.12.065","title":"U6 promoter-driven siRNA injection has nonspecific effects in zebrafish","year":2009,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"RNA interference; Gene silencing; Small interfering RNA; RNA silencing; Zebrafish; Trans-acting siRNA; Biology; Gene expression; RNA; RNA-induced silencing complex; Molecular biology; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005035806,0.0009189401,0.0007634644,0.0008400689,0.0006940624,0.0006967398,0.0008121248,0.001132635,0.004922525],"category_scores_gemma":[0.0003760075,0.0007780411,0.0007932936,0.0002822412,0.001056513,0.000762554,0.0004952283,0.001733446,0.002189285],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001123865,"about_ca_system_score_gemma":0.001075134,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00787958,"about_ca_topic_score_gemma":0.0141156,"domain_scores_codex":[0.999416,0.00004305679,0.00006227508,0.0002032142,0.0001504822,0.0001249681],"domain_scores_gemma":[0.9994849,0.000111318,0.0001416172,0.00008045374,0.00007788999,0.0001036944],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006020197,0.00001019636,0.00005680051,0.00003488415,0.000003753695,0.0000642282,0.00003057202,0.00003194432,0.9986824,0.0002316306,0.000110901,0.0006823388],"study_design_scores_gemma":[0.00001093758,0.00005207056,0.0009144454,0.000006806704,0.00001291379,0.0001110842,0.0000191832,0.0003362927,0.9970039,0.00004516524,0.001481369,0.000005882566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9339313,0.002727926,0.0352653,0.001009207,0.000353908,0.0002436165,0.004197967,0.002020804,0.02025001],"genre_scores_gemma":[0.9138152,0.001957693,0.02523065,0.0004810216,0.00004868988,0.0003788803,0.003106209,0.001326209,0.05365539],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00787958,"threshold_uncertainty_score":0.01646751,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06426615722759774,"score_gpt":0.3507785358925817,"score_spread":0.2865123786649839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}