{"id":"W2090827834","doi":"10.1016/j.bbrc.2009.12.065","title":"U6 promoter-driven siRNA injection has nonspecific effects in zebrafish","year":2009,"lang":"en","type":"article","venue":"Biochemical and Biophysical Research Communications","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"National Natural Science Foundation of China","keywords":"RNA interference; Gene silencing; Small interfering RNA; RNA silencing; Zebrafish; Trans-acting siRNA; Biology; Gene expression; RNA; RNA-induced silencing complex; Molecular biology; Gene; Cell biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002231688,0.0001285462,0.0001431132,0.00009976336,0.0002118572,0.00008446043,0.0005850464,0.0001718203,0.00000407212],"category_scores_gemma":[0.0002377276,0.0001147456,0.00006697913,0.0003351002,0.0005120205,0.00001035125,0.0003250826,0.0004180055,0.00002828762],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002994953,"about_ca_system_score_gemma":0.00006535245,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004678525,"about_ca_topic_score_gemma":0.00002968917,"domain_scores_codex":[0.9987125,0.0002050103,0.0001868195,0.0003590678,0.0002065928,0.000329968],"domain_scores_gemma":[0.9987528,0.00009291673,0.00002854664,0.0008294029,0.0001580871,0.0001381869],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000677216,0.0004395249,0.000194706,0.00001206359,0.00000987096,0.000001572316,0.0000488368,6.076741e-7,0.9897016,0.0005197055,0.002766482,0.006237358],"study_design_scores_gemma":[0.0007178986,0.00190736,0.02241116,0.0001328878,0.000009715843,0.00001152146,0.00008848366,0.0009126088,0.9600104,0.00316273,0.01030862,0.0003265766],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944236,0.0007620477,0.00008410194,0.003320532,0.00002178934,0.0002981348,0.000008675058,0.00001547615,0.001065681],"genre_scores_gemma":[0.9981862,0.0005729594,0.0006036226,0.0001500504,0.0001446405,0.00005087417,0.0001273029,0.000008513945,0.0001557983],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02969112,"threshold_uncertainty_score":0.467919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06426615722759774,"score_gpt":0.3507785358925817,"score_spread":0.2865123786649839,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}