{"id":"W2090849279","doi":"10.1002/jhet.5570380609","title":"Nucleic acid related compounds. 114. Synthesis of 2,6‐(disubstituted)purine 2′,3′‐dideoxynucleosides and selected cytotoxic, anti‐hepatitis b, and adenosine deaminase substrate activities","year":2001,"lang":"en","type":"article","venue":"Journal of Heterocyclic Chemistry","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Heritage; University of Alberta","funders":"","keywords":"Chemistry; Adenosine deaminase; Purine; Ribonucleoside; Stereochemistry; Nucleic acid; Adenosine; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002372769,0.0006121084,0.0002795154,0.0004585829,0.0002767802,0.0002091003,0.0003127234,0.0004731797,0.005795153],"category_scores_gemma":[0.0001969329,0.0002451953,0.0002383391,0.0003985621,0.0001432838,0.0001890616,0.0002009858,0.0004660721,0.002325725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003632081,"about_ca_system_score_gemma":0.0004157212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005450179,"about_ca_topic_score_gemma":0.001480063,"domain_scores_codex":[0.9998506,0.00003113838,0.00001337044,0.0000310939,0.00004188638,0.00003195284],"domain_scores_gemma":[0.9999036,0.00001633107,0.00001303788,0.00001926639,0.0000263206,0.00002148862],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008255415,0.00006084845,0.0001037003,0.0003514893,0.00001069776,0.0001534619,0.00003518986,0.0002876972,0.982029,0.000796962,0.0004514434,0.01563692],"study_design_scores_gemma":[0.00005360018,0.0008531965,0.000710587,0.00003214647,0.00002721653,0.0004192975,0.00001357526,0.0002362924,0.9491537,0.0001651334,0.04832331,0.00001180905],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7303199,0.07255103,0.06086463,0.0008089459,0.001106543,0.001827162,0.008608225,0.001373095,0.1225405],"genre_scores_gemma":[0.8306409,0.0242572,0.06652814,0.0005425888,0.0001084826,0.0007446529,0.009922372,0.0001462285,0.06710944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005795153,"threshold_uncertainty_score":0.01938671,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006659596151916561,"score_gpt":0.2217332219981624,"score_spread":0.2150736258462458,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}