{"id":"W2090875012","doi":"10.1016/s0301-4622(03)00037-1","title":"How large are the volume changes accompanying protein transitions and binding?","year":2003,"lang":"en","type":"article","venue":"Biophysical Chemistry","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"","keywords":"Chemistry; Folding (DSP implementation); Chemical physics; Macromolecule; Protein folding; Volume (thermodynamics); Helix (gastropod); Excluded volume; Molecule; Nucleic acid; Thermodynamics; Biophysics; Crystallography; Polymer; Biochemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005398427,0.0001548163,0.0001166637,0.00000626159,0.0001790556,0.00006772474,0.0001252213,0.000141496,0.000007449058],"category_scores_gemma":[0.0000487734,0.0001165507,0.00006227034,0.00007332465,0.0001105753,0.000003748897,0.00004596312,0.0001377797,0.000001931382],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000007406101,"about_ca_system_score_gemma":0.00002200823,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":9.61648e-7,"about_ca_topic_score_gemma":0.000003516313,"domain_scores_codex":[0.9992938,0.00002370697,0.00006523065,0.0002815147,0.00009428863,0.0002414621],"domain_scores_gemma":[0.9995652,0.000003899103,0.00005361398,0.0002705351,0.0000331467,0.00007354013],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00000870205,0.0000355968,0.0001422852,0.00004233103,0.00002035631,0.000002672626,0.00001474477,3.993689e-7,0.999247,0.0001350894,0.0001090934,0.0002417972],"study_design_scores_gemma":[0.0003473257,0.00002489099,0.000361019,0.00001778999,0.00001889077,0.00002322411,0.0003123459,0.00005086357,0.9711994,0.0001844251,0.02725356,0.000206254],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9970672,0.0002914062,0.0006822664,0.00133423,0.00002452597,0.0001670083,0.00008147127,0.00001760338,0.0003342966],"genre_scores_gemma":[0.9975585,0.00001418917,0.0002313292,0.0001202769,0.0002537393,0.00005446943,0.00006187765,0.00001673315,0.001688925],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02804752,"threshold_uncertainty_score":0.4752798,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00648560110831562,"score_gpt":0.207063371337818,"score_spread":0.2005777702295024,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}