{"id":"W2090887850","doi":"10.1002/em.1045","title":"Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in <i>Escherichia coli lacZ</i> strains","year":2001,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; University of Guelph; Vanderbilt University","keywords":"Mutagen; Escherichia coli; Cytochrome P450; Quinoxaline; Carcinogen; Recombinant DNA; Enzyme; Chemistry; Biochemistry; Indole test; Heterocyclic amine; Quinoline; Reductase; Heterocyclic compound; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002597455,0.0002482271,0.0002679352,0.00008895405,0.0002079587,0.0000150141,0.0001537784,0.0001564307,0.0001486773],"category_scores_gemma":[0.00000637789,0.0002001916,0.0000734088,0.00011689,0.0003521509,0.00007632809,0.0001560707,0.0002537625,0.000007789029],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003448351,"about_ca_system_score_gemma":0.000006687628,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000616907,"about_ca_topic_score_gemma":0.00002766624,"domain_scores_codex":[0.998625,0.0002046619,0.0003513559,0.0003389619,0.0001454564,0.0003345004],"domain_scores_gemma":[0.999472,0.00004542068,0.0001420089,0.0001829595,0.000004852217,0.0001527918],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006797926,0.0003405621,0.01643912,0.0000200063,0.00009025148,0.00005648197,0.0005168181,0.00008737716,0.9716526,0.00009700032,0.00001964991,0.01061221],"study_design_scores_gemma":[0.00249425,0.0001346026,0.2129511,0.000008965391,0.0002003807,0.00004348205,0.0003907328,0.0004586436,0.7620118,0.0003043352,0.02067028,0.0003314116],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958882,0.002654291,0.00006714023,0.0003215189,0.000127882,0.0004438801,0.0000675691,0.00001309429,0.0004164041],"genre_scores_gemma":[0.9947437,0.003806935,0.00005435392,0.001006494,0.00003452299,0.0000509967,0.00007343158,0.000028746,0.0002008298],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2096408,"threshold_uncertainty_score":0.8163579,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0358639784513549,"score_gpt":0.33260369998112,"score_spread":0.2967397215297651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}