{"id":"W2090887850","doi":"10.1002/em.1045","title":"Recombinant human P450 forms 1A1, 1A2, and 1B1 catalyze the bioactivation of heterocyclic amine mutagens in <i>Escherichia coli lacZ</i> strains","year":2001,"lang":"en","type":"article","venue":"Environmental and Molecular Mutagenesis","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Guelph","funders":"Natural Sciences and Engineering Research Council of Canada; University of Guelph; Vanderbilt University","keywords":"Mutagen; Escherichia coli; Cytochrome P450; Quinoxaline; Carcinogen; Recombinant DNA; Enzyme; Chemistry; Biochemistry; Indole test; Heterocyclic amine; Quinoline; Reductase; Heterocyclic compound; Gene; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004589661,0.0007028021,0.0003367019,0.0003898333,0.0001938077,0.0003790946,0.0003716976,0.0003970005,0.001631043],"category_scores_gemma":[0.0003158703,0.0003708606,0.0003064262,0.0004763358,0.000243894,0.0001807116,0.0002208366,0.000660381,0.001305944],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005771222,"about_ca_system_score_gemma":0.0002358824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001081532,"about_ca_topic_score_gemma":0.0013183,"domain_scores_codex":[0.9993808,0.0001545841,0.00004614411,0.0001074367,0.0002239332,0.00008706053],"domain_scores_gemma":[0.9998273,0.00003307952,0.00004095416,0.00003609318,0.00002979357,0.00003275133],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001597605,0.00005951088,0.0002629065,0.0000320426,0.000008120101,0.0000292115,0.00001500669,0.00008543592,0.9979152,0.0001895792,0.0001407966,0.001102424],"study_design_scores_gemma":[0.00004338189,0.0001919817,0.001551916,0.000004300807,0.00001670088,0.0002325253,0.00001369798,0.0006176676,0.9928643,0.00006757785,0.004390657,0.000005303682],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9628805,0.001602372,0.02854289,0.0003228977,0.00008956101,0.0004011592,0.002957844,0.0004917844,0.002711135],"genre_scores_gemma":[0.9376158,0.0012016,0.03104118,0.0001057552,0.0000389148,0.0003300416,0.01496509,0.000174518,0.01452718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001631043,"threshold_uncertainty_score":0.005456388,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0358639784513549,"score_gpt":0.33260369998112,"score_spread":0.2967397215297651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}