{"id":"W2090903342","doi":"10.1002/jbt.20057","title":"Usefulness of studies on the molecular mechanism of action of herbals/botanicals: The case of St. John's wort","year":2005,"lang":"en","type":"review","venue":"Journal of Biochemical and Molecular Toxicology","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Pregnane X receptor; Hypericum perforatum; CYP3A4; Mechanism of action; Mechanism (biology); Xenobiotic; Pharmacology; Drug; Kava; Medicine; Cytochrome P450; Traditional medicine; Chemistry; Nuclear receptor; Biochemistry; Enzyme; Transcription factor; Philosophy","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001854899,0.000555749,0.0008127402,0.001780219,0.0008632414,0.001358606,0.0006895353,0.003830726,0.003160318],"category_scores_gemma":[0.003240457,0.0002600746,0.0007696343,0.0008116559,0.003391142,0.004466705,0.001103201,0.003574012,0.0009860989],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001015263,"about_ca_system_score_gemma":0.000909435,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001230733,"about_ca_topic_score_gemma":0.001349567,"domain_scores_codex":[0.9991838,0.0003076516,0.0000827326,0.0001308963,0.0002011111,0.00009382112],"domain_scores_gemma":[0.9975861,0.001374864,0.0002909101,0.000188129,0.0004020444,0.0001578697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.001904533,0.0008908041,0.02322191,0.008424499,0.0003236632,0.3375336,0.008765178,0.0002969313,0.05903599,0.1002246,0.04237849,0.4169998],"study_design_scores_gemma":[0.0001269386,0.001008131,0.01570929,0.002884154,0.000372076,0.370531,0.008198598,0.0005132399,0.01301803,0.05698694,0.530507,0.000144552],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.09487996,0.7136285,0.00777184,0.1148093,0.00699627,0.0001671098,0.0001755242,0.00008103321,0.06149047],"genre_scores_gemma":[0.4515409,0.472744,0.01411066,0.03092233,0.01326704,0.0001126819,0.0001524952,0.00005817816,0.01709175],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.003830726,"threshold_uncertainty_score":0.01057237,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2102273078574637,"score_gpt":0.4793757838700026,"score_spread":0.2691484760125389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}