{"id":"W2090983971","doi":"10.1021/ma102354k","title":"Facile Construction of Multifunctional Nanocarriers Using Sequential Click Chemistry for Applications in Biology","year":2011,"lang":"en","type":"article","venue":"Macromolecules","topic":"Click Chemistry and Applications","field":"Chemistry","cited_by":28,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"","keywords":"Nanocarriers; Click chemistry; Dendrimer; Chemistry; Ethylene glycol; Combinatorial chemistry; Glutathione; Covalent bond; Conjugated system; Alkyne; PEG ratio; Azide; Polymer chemistry; Organic chemistry; Drug delivery; Polymer","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00005024291,0.0001332884,0.0001655773,0.00002540894,0.00009165642,0.00000581213,0.0001588817,0.0001734324,0.0006958296],"category_scores_gemma":[0.00003253341,0.0001496828,0.0001018625,0.0001212782,0.0002441572,0.0000308022,0.00004082798,0.0001001443,0.000002181715],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005957767,"about_ca_system_score_gemma":0.00006469827,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008855071,"about_ca_topic_score_gemma":0.000004663293,"domain_scores_codex":[0.9991251,0.000005767892,0.0003261983,0.0002972867,0.00005826621,0.0001873324],"domain_scores_gemma":[0.9994168,0.00004773821,0.0001603334,0.0002464947,0.00007364271,0.00005502872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003105698,0.00009441606,0.006417574,0.000152389,0.00002625399,3.292086e-7,0.00009102087,0.00001550374,0.9903331,0.00213165,0.000007310514,0.0006993465],"study_design_scores_gemma":[0.0004516317,0.000004523134,0.0000575736,0.00001615174,0.00002727395,0.00001619243,0.0004782861,0.0003559816,0.9923226,0.0033206,0.002806028,0.0001431558],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748276,0.00004771325,0.01821504,0.00001132692,0.00002541343,0.0001444655,0.0006038873,0.00004144034,0.006083117],"genre_scores_gemma":[0.9877431,0.000005543328,0.01137944,0.000007252606,0.00006776186,0.0002519745,0.0004227022,0.00001536168,0.0001068183],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01291555,"threshold_uncertainty_score":0.7618846,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03890409375380111,"score_gpt":0.2918305812161052,"score_spread":0.2529264874623041,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}