{"id":"W2090994422","doi":"10.1385/endo:16:1:07","title":"The Endogenous Progesterone Metabolite, 5α-Pregnane-3,20-dione, Decreases Cell-Substrate Attachment, Adhesion Plaques, Vinculin Expression, and Polymerized F-actin in MCF-7 Breast Cancer Cells","year":2001,"lang":"en","type":"article","venue":"Endocrine","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Vinculin; Cell adhesion; Actin; Cytoskeleton; Cell biology; Cell adhesion molecule; Neural cell adhesion molecule; Focal adhesion; Actin cytoskeleton; Chemistry; MCF-7; Biology; Cancer cell; Cell; Biochemistry; Cancer; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001166791,0.000195657,0.0002647258,0.0002623884,0.0002633535,0.0002795226,0.0001877401,0.0002384075,0.001461321],"category_scores_gemma":[0.0001625937,0.0002308586,0.0001794564,0.0001724689,0.0002202363,0.0001425857,0.0001124282,0.000384647,0.0004344861],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004046647,"about_ca_system_score_gemma":0.000263339,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002851304,"about_ca_topic_score_gemma":0.00425159,"domain_scores_codex":[0.9998154,0.00003390558,0.00001127799,0.00001948598,0.00005817284,0.00006174875],"domain_scores_gemma":[0.9998771,0.00004171694,0.00001430089,0.00002037453,0.0000109826,0.00003557271],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002168178,0.0000371868,0.0001479623,0.00002363956,0.000004503997,0.00008330398,0.00001611775,0.00002567203,0.9985837,0.00005515206,0.00006204771,0.000743962],"study_design_scores_gemma":[0.00001801139,0.0003675974,0.00695458,0.000003767819,0.00001401856,0.0002978911,0.00004451767,0.0002835803,0.9902209,0.00002828555,0.001763599,0.000003071933],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9930952,0.004274382,0.0003172792,0.0001764625,0.00004076455,0.000006312324,0.0002417903,0.00004029485,0.00180756],"genre_scores_gemma":[0.9892764,0.002551887,0.0004568338,0.00007790724,0.00001899611,0.00001648941,0.0006049577,0.00001651277,0.006979964],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002851304,"threshold_uncertainty_score":0.005669415,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008782605788529524,"score_gpt":0.2459269907955671,"score_spread":0.2371443850070376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}