{"id":"W2090994422","doi":"10.1385/endo:16:1:07","title":"The Endogenous Progesterone Metabolite, 5α-Pregnane-3,20-dione, Decreases Cell-Substrate Attachment, Adhesion Plaques, Vinculin Expression, and Polymerized F-actin in MCF-7 Breast Cancer Cells","year":2001,"lang":"en","type":"article","venue":"Endocrine","topic":"Estrogen and related hormone effects","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Vinculin; Cell adhesion; Actin; Cytoskeleton; Cell biology; Cell adhesion molecule; Neural cell adhesion molecule; Focal adhesion; Actin cytoskeleton; Chemistry; MCF-7; Biology; Cancer cell; Cell; Biochemistry; Cancer; Signal transduction","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001322852,0.0003374466,0.0002807215,0.00005815747,0.0002301057,0.00006813714,0.0002275443,0.0001344144,0.00003357658],"category_scores_gemma":[0.00001654528,0.0002360163,0.00008881461,0.0001569847,0.0001172188,0.00001760427,0.0001684605,0.000232363,0.00000932753],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002570682,"about_ca_system_score_gemma":0.00009058631,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003729806,"about_ca_topic_score_gemma":0.00007211971,"domain_scores_codex":[0.9981266,0.0002153329,0.0003589554,0.0005190568,0.0001896017,0.0005904285],"domain_scores_gemma":[0.9991178,0.00005202312,0.0001602166,0.000403081,0.00004641501,0.0002204917],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0006937427,0.0002105636,0.009107703,0.00002576766,0.00005182095,0.0001703716,0.00004119643,0.00001986575,0.986274,0.000004288662,0.0002525453,0.003148124],"study_design_scores_gemma":[0.002277362,0.0001797708,0.003394649,0.0000760939,0.00004788165,0.0006308497,0.0000794244,0.00002163644,0.9832797,0.000009179002,0.009716825,0.0002866494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9455376,0.05298863,0.0000132159,0.0002298447,0.0001657535,0.0005215914,0.0000555177,0.00003318473,0.0004547196],"genre_scores_gemma":[0.9685363,0.02944853,0.000140184,0.00008605961,0.0001764686,0.000166296,0.0001288578,0.0000465942,0.001270758],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02354009,"threshold_uncertainty_score":0.9624466,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008782605788529524,"score_gpt":0.2459269907955671,"score_spread":0.2371443850070376,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}