{"id":"W2091003490","doi":"10.1021/bc050297w","title":"Extension of the Single Amino Acid Chelate Concept (SAAC) to Bifunctional Biotin Analogues for Complexation of the M(CO)<sub>3</sub><sup>+1</sup> Core (M = Tc and Re):  Syntheses, Characterization, Biotinidase Stability, and Avidin Binding","year":2006,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; National Institutes of Health","keywords":"Chemistry; Avidin; Biotin; Chelation; Bifunctional; Histidine; Lysine; Cysteine; Stereochemistry; Amino acid; Combinatorial chemistry; Biochemistry; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002291671,0.0004576761,0.0003114405,0.0001860357,0.0001593983,0.0003413749,0.0004414218,0.000614101,0.000680187],"category_scores_gemma":[0.000307483,0.000168206,0.0002389077,0.0001702985,0.0003770029,0.0004057801,0.0003564364,0.0006376341,0.0005239482],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000333431,"about_ca_system_score_gemma":0.0002540665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005728506,"about_ca_topic_score_gemma":0.0007313999,"domain_scores_codex":[0.999868,0.00002281258,0.00001125346,0.00003511306,0.00004211421,0.0000207375],"domain_scores_gemma":[0.9997895,0.00003331959,0.00005584788,0.00002224897,0.00006622279,0.00003272434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008297003,0.00001091607,0.00008862961,0.00008093804,0.000007077455,0.0000331985,0.00002749417,0.0001442589,0.9948081,0.0004174128,0.00007330568,0.004225686],"study_design_scores_gemma":[0.0000121633,0.0002966419,0.0002803056,0.000003785896,0.000009577964,0.0003872897,0.00001084187,0.001214236,0.9927084,0.00006212197,0.005006005,0.00000860414],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8886976,0.005841949,0.09973925,0.000345029,0.0001755794,0.0003272546,0.0002362616,0.0006235685,0.004013583],"genre_scores_gemma":[0.9303895,0.001657804,0.06442795,0.000198198,0.00002861261,0.0001419497,0.0001592875,0.00005515508,0.002941544],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000680187,"threshold_uncertainty_score":0.002419233,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0513773443724586,"score_gpt":0.2757023416896398,"score_spread":0.2243249973171812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}