{"id":"W2091003490","doi":"10.1021/bc050297w","title":"Extension of the Single Amino Acid Chelate Concept (SAAC) to Bifunctional Biotin Analogues for Complexation of the M(CO)<sub>3</sub><sup>+1</sup> Core (M = Tc and Re):  Syntheses, Characterization, Biotinidase Stability, and Avidin Binding","year":2006,"lang":"en","type":"article","venue":"Bioconjugate Chemistry","topic":"Radiopharmaceutical Chemistry and Applications","field":"Medicine","cited_by":45,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"National Institute of Allergy and Infectious Diseases; U.S. Public Health Service; National Institutes of Health","keywords":"Chemistry; Avidin; Biotin; Chelation; Bifunctional; Histidine; Lysine; Cysteine; Stereochemistry; Amino acid; Combinatorial chemistry; Biochemistry; Organic chemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002063751,0.00019534,0.0002856618,0.00002394766,0.0002180547,0.00002178436,0.000123622,0.0001528925,0.00003696213],"category_scores_gemma":[0.0003456667,0.0001378452,0.00009969945,0.0002608853,0.0005548797,0.00005068391,0.00008670421,0.0001384098,8.347305e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005673627,"about_ca_system_score_gemma":0.00005383011,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007263161,"about_ca_topic_score_gemma":7.724587e-7,"domain_scores_codex":[0.9987094,0.00002561621,0.0004798476,0.0003845659,0.0002081431,0.0001923859],"domain_scores_gemma":[0.9988363,0.0001828432,0.0002890278,0.000376668,0.000204057,0.0001110995],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001159647,0.0001681998,0.007208637,0.0004841065,0.00002720037,2.561755e-7,0.0000830138,0.000007425807,0.9912871,0.00005136209,0.0001330709,0.0004336722],"study_design_scores_gemma":[0.0006130373,0.0000398363,0.0246007,0.0002770415,0.0001085766,0.00002224755,0.0001376404,0.0005005032,0.9724749,0.00005345594,0.001039073,0.0001329863],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966055,0.0001160695,0.0001507404,0.001342048,0.00002641695,0.0007354823,0.0008622859,0.00002654353,0.0001349262],"genre_scores_gemma":[0.9989455,0.00001941455,0.0001512387,0.000110153,0.0001503946,0.00003787001,0.0005002497,0.0000191062,0.00006605079],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01881219,"threshold_uncertainty_score":0.5621165,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0513773443724586,"score_gpt":0.2757023416896398,"score_spread":0.2243249973171812,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}