{"id":"W2091006935","doi":"10.1111/j.1399-0004.2006.00673.x","title":"Application of <i>BRCA1</i> and <i>BRCA2</i> mutation carrier prediction models in breast and/or ovarian cancer families of French Canadian descent","year":2006,"lang":"en","type":"article","venue":"Clinical Genetics","topic":"BRCA gene mutations in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":35,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Hôpital Notre-Dame; Université de Montréal; Hôtel-Dieu de Montréal; Centre Hospitalier de l’Université de Montréal; McGill University","funders":"","keywords":"Breast cancer; Mutation; Ovarian cancer; Medicine; Oncology; Cancer; Internal medicine; Family history; Genetic testing; Genetics; Gynecology; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002175993,0.0001083814,0.0001774069,0.00006910878,0.00002910753,0.000007291793,0.00008314491,0.0002212328,0.000003669098],"category_scores_gemma":[0.00002476369,0.0001082604,0.00003432575,0.0001411108,0.0002303882,0.000005211074,0.00004025661,0.00007801676,1.595828e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004883438,"about_ca_system_score_gemma":0.0004266018,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.02487817,"about_ca_topic_score_gemma":0.09288232,"domain_scores_codex":[0.9988301,0.00005665187,0.0005487276,0.0003159895,0.0001006069,0.0001479333],"domain_scores_gemma":[0.9993397,0.00002749929,0.0001527501,0.0002322786,0.0001614252,0.00008635447],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001802104,0.0002125577,0.7920557,0.0001534498,0.00009904261,0.000002075246,0.000317496,0.0361922,0.04484547,0.0002857865,0.001214767,0.1244412],"study_design_scores_gemma":[0.001710717,0.0002822972,0.9382325,0.00005272053,0.00009263594,0.00002080379,0.0001646545,0.03250945,0.02169137,0.001239187,0.00375794,0.0002456981],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908901,0.002389826,0.005355014,0.0001840038,0.0001291736,0.0003043796,0.000489024,0.000003973015,0.0002544553],"genre_scores_gemma":[0.9951987,0.002193831,0.002121737,0.0001126248,0.0001460022,0.00004185578,0.0001316397,0.00001575303,0.00003784705],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1461768,"threshold_uncertainty_score":0.9816152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01723855419057786,"score_gpt":0.292809206140206,"score_spread":0.2755706519496282,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}