{"id":"W2091013260","doi":"10.1002/ejoc.200600284","title":"Novel Synthetic Strategy Towards Taxol by Macrocyclization Reaction – Conformational Requirement of Ring A","year":2006,"lang":"en","type":"article","venue":"European Journal of Organic Chemistry","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Chemistry; Ring (chemistry); Stereochemistry; Combinatorial chemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001010907,0.000373729,0.0002647737,0.0002519265,0.0001863924,0.0002253832,0.0002537218,0.0002490974,0.001457624],"category_scores_gemma":[0.00007863343,0.0001189329,0.0001817032,0.0001709971,0.0002290195,0.0002129131,0.0002959264,0.0004967826,0.0007280008],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002329501,"about_ca_system_score_gemma":0.0005320612,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005646839,"about_ca_topic_score_gemma":0.00070292,"domain_scores_codex":[0.9999193,0.00001136444,0.000007108318,0.00002080447,0.0000103036,0.00003107647],"domain_scores_gemma":[0.9999363,0.000007199327,0.00001586827,0.0000077925,0.000008234146,0.00002454097],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002135932,0.00008510107,0.0001975605,0.0001545324,0.000009715561,0.0009066823,0.00008099619,0.0008822753,0.9789603,0.002786525,0.0004437918,0.01527897],"study_design_scores_gemma":[0.00009230711,0.0008796752,0.000587859,0.00001293074,0.00001768128,0.0006825012,0.00004060832,0.0008064397,0.9775811,0.000476001,0.01879355,0.00002924364],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9298915,0.004953195,0.04178761,0.0007158103,0.0004491462,0.0007139621,0.0008173006,0.0004702586,0.02020133],"genre_scores_gemma":[0.9797799,0.001975408,0.01325662,0.0001384354,0.00003788636,0.0001060625,0.0002322663,0.00003146262,0.004441975],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001457624,"threshold_uncertainty_score":0.004876256,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01808994674897337,"score_gpt":0.2647975971216491,"score_spread":0.2467076503726757,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}