{"id":"W2091042015","doi":"10.1529/biophysj.108.138297","title":"Trans-Channel Interactions in Batrachotoxin-Modified Skeletal Muscle Sodium Channels: Voltage-Dependent Block by Cytoplasmic Amines, and the Influence of μ-Conotoxin GIIIA Derivatives and Permeant Ions","year":2008,"lang":"en","type":"article","venue":"Biophysical Journal","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":3,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"Medical Research Council; National Institutes of Health; Alberta Heritage Foundation for Medical Research; Fondation pour la Recherche Médicale; Heart and Stroke Foundation of Canada; University of Calgary; Canadian Institutes of Health Research; Nunavut Wildlife Research Trust","keywords":"Batrachotoxin; Chemistry; Sodium channel; Ion; Amine gas treating; Sodium; Biophysics; Ion channel; Biochemistry; Receptor; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002135365,0.0001948534,0.0002787938,0.00008991559,0.000246712,0.0003258401,0.0003717182,0.0002923922,0.001000852],"category_scores_gemma":[0.0002670031,0.0001334994,0.0001658695,0.0001389828,0.0003723861,0.0004722927,0.0002252733,0.0005426428,0.0002225561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004566705,"about_ca_system_score_gemma":0.0002259944,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002064976,"about_ca_topic_score_gemma":0.003089345,"domain_scores_codex":[0.9998259,0.00002799016,0.00001472214,0.00003143986,0.00004666457,0.00005325583],"domain_scores_gemma":[0.9998234,0.00005552937,0.00003666867,0.00002548699,0.00002232397,0.0000365842],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000271068,0.00001520363,0.0001155681,0.00001594533,0.000005149467,0.0000686768,0.00004236884,0.00006167783,0.9988509,0.0001734353,0.00001219602,0.0003678629],"study_design_scores_gemma":[0.00002157446,0.0002123438,0.002636381,0.00000358358,0.00001408102,0.0001370958,0.00005348073,0.001250565,0.9949566,0.00004943174,0.0006601693,0.000004678008],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9984523,0.0003858143,0.0004909291,0.00002649846,0.000008684416,0.000005420882,0.00003173278,0.00001158164,0.0005870745],"genre_scores_gemma":[0.9982856,0.0002628622,0.0003705103,0.00001992304,0.000004568059,0.000007052317,0.00009214747,0.00001254207,0.0009447391],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002064976,"threshold_uncertainty_score":0.004105985,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01176366106252702,"score_gpt":0.2351979176732818,"score_spread":0.2234342566107548,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}