{"id":"W2091050052","doi":"10.1038/sj.onc.1207554","title":"Bcl-xES, a BH4- and BH2-containing antiapoptotic protein, delays Bax oligomer formation and binds Apaf-1, blocking procaspase-9 activation","year":2004,"lang":"en","type":"article","venue":"Oncogene","topic":"Cell death mechanisms and regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":36,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hôpital Notre-Dame","funders":"National Cancer Institute","keywords":"Biology; Apoptosis; Programmed cell death; Molecular biology; Death domain; Camptothecin; Cancer research; Cell biology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002114988,0.0003405391,0.0003173054,0.0003249429,0.000350073,0.0003946819,0.000319252,0.0002826842,0.003407813],"category_scores_gemma":[0.0001997617,0.0002242765,0.0002557256,0.0001865302,0.0003152523,0.0004705469,0.0002352867,0.0009736866,0.0007706684],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005321557,"about_ca_system_score_gemma":0.0003289798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004448801,"about_ca_topic_score_gemma":0.0008121441,"domain_scores_codex":[0.9998112,0.00003638807,0.00001285223,0.00002397991,0.00004452572,0.00007097082],"domain_scores_gemma":[0.9998226,0.00004233426,0.00003541061,0.00002360291,0.00002271414,0.00005333082],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000708221,0.000100967,0.0001726258,0.00004027651,0.000008211219,0.00004739139,0.00001568286,0.00004770163,0.995776,0.0004566178,0.0001735962,0.002452772],"study_design_scores_gemma":[0.00004167199,0.000275601,0.001009777,0.000002203395,0.000007104572,0.0002207478,0.00001885565,0.0004225856,0.9962313,0.00008590784,0.001681788,0.000002375022],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9883839,0.002755222,0.005345093,0.0002611809,0.00009371805,0.00002317803,0.0002139301,0.0003002902,0.002623476],"genre_scores_gemma":[0.9903415,0.001070188,0.002437026,0.00007325574,0.00002475698,0.00002417027,0.000477934,0.000032243,0.005518889],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003407813,"threshold_uncertainty_score":0.01140022,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007855117407913633,"score_gpt":0.2153653410052622,"score_spread":0.2075102235973486,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}