{"id":"W2091082924","doi":"10.1074/jbc.m109.088625","title":"Dopamine D1-D2 Receptor Heteromer-mediated Calcium Release Is Desensitized by D1 Receptor Occupancy with or without Signal Activation","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Centre for Addiction and Mental Health","funders":"National Institute on Drug Abuse","keywords":"Dopamine receptor D2; Chemistry; Agonist; Cell biology; G protein-coupled receptor; Receptor; Dopamine receptor; Dopamine receptor D1; Biophysics; Endogenous agonist; Desensitization (medicine); Biochemistry; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001978859,0.0002649606,0.0003665024,0.0001309354,0.0001514895,0.0003898729,0.0002458394,0.0002934361,0.0019758],"category_scores_gemma":[0.0001720726,0.0001496124,0.0003081659,0.0001573384,0.0002128508,0.0002493362,0.0002462744,0.0005286514,0.0004098012],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004862619,"about_ca_system_score_gemma":0.0001985129,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006591204,"about_ca_topic_score_gemma":0.001289081,"domain_scores_codex":[0.9997622,0.00002698352,0.00001856067,0.00007321087,0.0000465781,0.00007232889],"domain_scores_gemma":[0.9999273,0.00001610251,0.00002045156,0.00001128426,0.00000676063,0.00001803705],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008430373,0.00001227718,0.00007385677,0.00002654053,0.000004323302,0.00003603283,0.00001050439,0.0000232293,0.9993432,0.00005638104,0.00001782853,0.0003114083],"study_design_scores_gemma":[0.00004448805,0.0001446959,0.01096826,0.000006429399,0.00001495399,0.0003309114,0.00003819641,0.001141081,0.9856789,0.00006971407,0.001555013,0.000007395544],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9966797,0.0008863666,0.001062983,0.00009085703,0.00001514909,0.00001353991,0.0002709721,0.00003744659,0.0009430155],"genre_scores_gemma":[0.9965262,0.0004664487,0.0008486157,0.00005951913,0.000006094927,0.00003796908,0.0003814899,0.00001615452,0.001657512],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0019758,"threshold_uncertainty_score":0.006609738,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01681769457374288,"score_gpt":0.2555156626050982,"score_spread":0.2386979680313553,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}