{"id":"W2091087622","doi":"10.2174/187152007781058622","title":"Harnessing Telomerase in Cancer Therapeutics","year":2007,"lang":"en","type":"review","venue":"Anti-Cancer Agents in Medicinal Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Jewish General Hospital","keywords":"Telomerase; Telomere; Telomerase reverse transcriptase; Cancer; Biology; Cancer research; Genetic enhancement; Cancer cell; Oligonucleotide; Cancer immunotherapy; Gene; Immunotherapy; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003590194,0.0005739179,0.001116425,0.0001381413,0.00004541828,0.00002608993,0.0006175904,0.0007762611,0.0003428019],"category_scores_gemma":[0.00002907192,0.0005070741,0.0002609601,0.0003936662,0.000165091,0.000006766776,0.0001601934,0.0007656002,0.00001149625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002149127,"about_ca_system_score_gemma":0.0006418574,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002709537,"about_ca_topic_score_gemma":0.0001069643,"domain_scores_codex":[0.9973453,0.00006449098,0.0008231196,0.0008178145,0.0003271372,0.000622093],"domain_scores_gemma":[0.9989665,0.00002313273,0.0003205638,0.0005051731,0.00006900321,0.0001156584],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004073431,0.0001500292,0.002609194,0.007332582,0.0002345535,0.0001582384,0.00006456367,0.00001604115,0.007575011,2.001338e-7,0.001286077,0.9805328],"study_design_scores_gemma":[0.0006384705,0.00003666287,0.0001930315,0.01442183,0.00024754,0.00003001998,0.00008701881,0.00001017956,0.02106971,0.00000234823,0.9625892,0.0006739892],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.05359186,0.9446087,0.00001448719,0.00002673223,0.0004382899,0.0002607888,0.0000597418,0.000008937954,0.0009904506],"genre_scores_gemma":[0.005969875,0.9902501,0.00002247752,0.0005417226,0.0009951055,0.0001515329,0.0002690345,0.00007298386,0.001727225],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9798588,"threshold_uncertainty_score":0.9997381,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1147767581882077,"score_gpt":0.4320263965930206,"score_spread":0.3172496384048129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}