{"id":"W2091087622","doi":"10.2174/187152007781058622","title":"Harnessing Telomerase in Cancer Therapeutics","year":2007,"lang":"en","type":"review","venue":"Anti-Cancer Agents in Medicinal Chemistry","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":25,"is_retracted":false,"has_abstract":true,"ca_institutions":"Jewish General Hospital; McGill University","funders":"Jewish General Hospital","keywords":"Telomerase; Telomere; Telomerase reverse transcriptase; Cancer; Biology; Cancer research; Genetic enhancement; Cancer cell; Oligonucleotide; Cancer immunotherapy; Gene; Immunotherapy; Computational biology; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000513448,0.0007509295,0.0009559436,0.001282475,0.0003413494,0.0008142867,0.0006438709,0.001334076,0.002735162],"category_scores_gemma":[0.0002700349,0.000287526,0.0003489301,0.001045716,0.0006328075,0.001387844,0.0006317355,0.001786412,0.002778613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007657394,"about_ca_system_score_gemma":0.0006590328,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000416334,"about_ca_topic_score_gemma":0.00084665,"domain_scores_codex":[0.9998068,0.00003869035,0.00001564562,0.00002824574,0.00008970109,0.00002086402],"domain_scores_gemma":[0.9999143,0.0000353991,0.00001229436,0.000005514427,0.0000196669,0.00001283234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007895263,0.000157806,0.0001539474,0.008100569,0.0000576925,0.0005790718,0.0001679906,0.00109612,0.02160821,0.02734552,0.0261368,0.9145173],"study_design_scores_gemma":[0.00002874712,0.0001310812,0.0002381649,0.0007925485,0.00003038041,0.001085134,0.00003801023,0.0001840016,0.003238326,0.005452806,0.9887665,0.00001432113],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.000594363,0.9924415,0.001075128,0.0005584512,0.0003675696,0.0000144051,0.00001062582,0.0000255544,0.004912344],"genre_scores_gemma":[0.003427441,0.9915611,0.0009485948,0.0004394544,0.0002681967,0.0000219358,0.00002156821,0.000003111555,0.00330854],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002735162,"threshold_uncertainty_score":0.009150028,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1147767581882077,"score_gpt":0.4320263965930206,"score_spread":0.3172496384048129,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}