{"id":"W2091099123","doi":"10.1111/j.1365-2982.2006.00851.x","title":"Colonic luminal proteases activate colonocyte proteinase‐activated receptor‐2 and regulate paracellular permeability in mice","year":2006,"lang":"en","type":"article","venue":"Neurogastroenterology & Motility","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":55,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"","keywords":"Proteases; Protease; Trypsin; Protease-activated receptor 2; Paracellular transport; Chemistry; Receptor; Mast cell; Intestinal permeability; Serine protease; Pharmacology; Biochemistry; Biology; Enzyme; Permeability (electromagnetism); Immunology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0004767082,0.0003356426,0.0006435654,0.0001541594,0.0001260307,0.00002411694,0.0001197823,0.0002234428,0.0001198906],"category_scores_gemma":[0.0001284807,0.000336314,0.0001135985,0.0002262964,0.000390872,0.0001652232,0.0001160531,0.0005599696,0.00001434317],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000151287,"about_ca_system_score_gemma":0.00007216583,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003193067,"about_ca_topic_score_gemma":0.0002273921,"domain_scores_codex":[0.9970625,0.0006289018,0.0005726716,0.0008791577,0.0002449555,0.0006118117],"domain_scores_gemma":[0.9989333,0.00006380266,0.000225665,0.000475948,0.0001167846,0.0001845434],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0009689328,0.001284143,0.4778883,0.0001135576,0.00003488775,0.00005802449,0.00004894084,0.00002368173,0.5192282,0.0000562567,0.00006660358,0.0002285613],"study_design_scores_gemma":[0.003474066,0.001475385,0.8491674,0.00004795123,0.00006659186,0.0001081666,0.00002249213,0.0005530145,0.1444383,0.0002211483,0.0003743341,0.00005106831],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942852,0.0000483754,0.00006754924,0.003045792,0.000152303,0.002175147,0.00001918703,0.0001456773,0.00006074048],"genre_scores_gemma":[0.9985582,0.00000860469,0.000511265,0.0004553406,0.00007361412,0.0001871821,0.00005837417,0.00003147229,0.0001159198],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.3747898,"threshold_uncertainty_score":0.9999089,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01267300221110571,"score_gpt":0.2426157644211095,"score_spread":0.2299427622100038,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}