{"id":"W2091101912","doi":"10.1074/jbc.m110.169482","title":"Potentiation of Ligand Binding through Cooperative Effects in Monoamine Oxidase B","year":2010,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"National Institute of Neurological Disorders and Stroke; National Institute of General Medical Sciences; Fondazione Cariplo; National Institutes of Health; Canadian Institutes of Health Research; Ministero dell’Istruzione, dell’Università e della Ricerca","keywords":"Allosteric regulation; Imidazoline receptor; Chemistry; Tranylcypromine; Stereochemistry; Long-term potentiation; Binding site; Ligand (biochemistry); Side chain; Monoamine oxidase; Monoamine oxidase B; Monoamine oxidase A; Biochemistry; Receptor; Enzyme; Pharmacology; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002453566,0.0002682784,0.0003896729,0.0001115892,0.0002783317,0.0003698023,0.0006694401,0.0003567864,0.001126366],"category_scores_gemma":[0.0003734195,0.0002990288,0.0002435125,0.0001367442,0.0004392458,0.0004543653,0.0004673561,0.000520616,0.000376009],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005033418,"about_ca_system_score_gemma":0.0002859258,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001366384,"about_ca_topic_score_gemma":0.001720567,"domain_scores_codex":[0.9998069,0.00003731059,0.00001250756,0.00004126745,0.00007528513,0.00002662978],"domain_scores_gemma":[0.9998029,0.00004719627,0.00005335607,0.00003585083,0.0000234845,0.00003723228],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002435178,0.0001308541,0.0008296954,0.0001262081,0.00002513194,0.0002897587,0.00008702791,0.001162271,0.9920757,0.0009965408,0.0001098406,0.003923407],"study_design_scores_gemma":[0.0003495777,0.001003965,0.009874661,0.0000231708,0.00004929118,0.0009464845,0.0001013835,0.02667814,0.9544008,0.000838,0.005694814,0.00003968004],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9908047,0.00174962,0.004875548,0.00016393,0.00001911554,0.00004492064,0.00004058234,0.0001266851,0.002174976],"genre_scores_gemma":[0.9957812,0.0007090799,0.002530094,0.00006021078,0.000009614129,0.00002394638,0.00006208115,0.000009263866,0.0008146223],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001366384,"threshold_uncertainty_score":0.003768086,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01715422664238201,"score_gpt":0.277220258793996,"score_spread":0.2600660321516139,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}