{"id":"W2091132744","doi":"10.1021/jo800195j","title":"A Convenient Route to <i>N</i>-[2-(Fmoc)aminoethyl]glycine Esters and PNA Oligomerization Using a Bis-<i>N</i>-Boc Nucleobase Protecting Group Strategy","year":2008,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Francis Crick Institute","keywords":"Chemistry; Protecting group; Nucleobase; Peptide nucleic acid; Monomer; Glycine; Peptide; Peptide synthesis; Nucleic acid; Hydrolysis; Hydrochloride; Ether; Amino acid; Stereochemistry; Organic chemistry; Combinatorial chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001018491,0.0005645814,0.0002556684,0.0001653808,0.0001612231,0.0001826978,0.0004195541,0.0003761576,0.002361956],"category_scores_gemma":[0.00009846201,0.0002298933,0.0001987163,0.0001494119,0.000124764,0.0002719559,0.0002633879,0.0006607191,0.001887638],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001802895,"about_ca_system_score_gemma":0.0003192906,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002671242,"about_ca_topic_score_gemma":0.0004382569,"domain_scores_codex":[0.999907,0.00001407891,0.000007578537,0.00002791137,0.00001972384,0.00002367411],"domain_scores_gemma":[0.9999576,0.000006079139,0.00001494813,0.000004469568,0.00000562236,0.0000114094],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002046818,0.00001557923,0.00002035624,0.00007301779,0.000003650429,0.0000852505,0.00001321003,0.00008136529,0.9965018,0.0002441077,0.00006751746,0.002873659],"study_design_scores_gemma":[0.000008612647,0.0001470125,0.0002546892,0.000007112162,0.000007187178,0.0003984622,0.000007843923,0.0002639521,0.9903917,0.00009751913,0.008407083,0.000008780991],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7315555,0.009005222,0.2263437,0.0004301761,0.0003722255,0.0007670968,0.001706467,0.001916571,0.02790308],"genre_scores_gemma":[0.8630382,0.00589396,0.1138249,0.0002507476,0.00005209823,0.0004400887,0.001418337,0.0002862341,0.01479546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002361956,"threshold_uncertainty_score":0.007901549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323089091909343,"score_gpt":0.2262973254615769,"score_spread":0.2130664345424834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}