{"id":"W2091132744","doi":"10.1021/jo800195j","title":"A Convenient Route to <i>N</i>-[2-(Fmoc)aminoethyl]glycine Esters and PNA Oligomerization Using a Bis-<i>N</i>-Boc Nucleobase Protecting Group Strategy","year":2008,"lang":"en","type":"article","venue":"The Journal of Organic Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; Francis Crick Institute","keywords":"Chemistry; Protecting group; Nucleobase; Peptide nucleic acid; Monomer; Glycine; Peptide; Peptide synthesis; Nucleic acid; Hydrolysis; Hydrochloride; Ether; Amino acid; Stereochemistry; Organic chemistry; Combinatorial chemistry; Polymer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003511675,0.0002501118,0.0002690152,0.00002584768,0.0002470046,0.00003025346,0.0003293139,0.0001610706,0.00005227608],"category_scores_gemma":[0.0001736817,0.0001999784,0.00009024341,0.0001987312,0.0001573488,0.00001562549,0.0001763041,0.0003327588,0.000001530118],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00005881237,"about_ca_system_score_gemma":0.0002010407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001436077,"about_ca_topic_score_gemma":0.000002493614,"domain_scores_codex":[0.9986706,0.0000575533,0.000481784,0.0002387675,0.000257153,0.0002941785],"domain_scores_gemma":[0.998836,0.00002588168,0.000414022,0.0003423622,0.0001516156,0.0002301652],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002394647,0.00006164896,0.001085873,0.00006640262,0.00007834144,0.00003230255,0.0002344646,0.00005838786,0.9976051,3.639877e-7,0.0001692321,0.0003683687],"study_design_scores_gemma":[0.001023036,0.0002019786,0.0003261408,0.00008148308,0.00009051925,0.003966461,0.0008739522,0.00007063428,0.9916934,0.000006296817,0.001418336,0.0002477334],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996606,0.000774586,0.001958007,0.0002184402,0.00007525927,0.0001451695,0.000008504714,0.0000113344,0.000202709],"genre_scores_gemma":[0.9979346,0.0004874982,0.0006663783,0.0002464811,0.0004389925,0.000002151666,0.00001072569,0.00004603205,0.0001671618],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005911722,"threshold_uncertainty_score":0.8154883,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01323089091909343,"score_gpt":0.2262973254615769,"score_spread":0.2130664345424834,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}