{"id":"W2091151601","doi":"10.1074/jbc.m111685200","title":"Amino Acid Residues in the P6-P′3 Region of Thrombin-activable Fibrinolysis Inhibitor (TAFI) Do Not Determine the Thrombomodulin Dependence of TAFI Activation","year":2002,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Blood Coagulation and Thrombosis Mechanisms","field":"Medicine","cited_by":20,"is_retracted":false,"has_abstract":true,"ca_institutions":"Kingston Health Sciences Centre; Queen's University","funders":"","keywords":"Thrombomodulin; Thrombin; Chemistry; Protein C; Fibrinogen; Mutant; Biochemistry; Molecular biology; Active site; Enzyme; Biology; Immunology; Gene; Platelet","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001522127,0.000383661,0.0002230316,0.000101255,0.0001317723,0.0002974816,0.0003281072,0.0003508098,0.000967438],"category_scores_gemma":[0.0003833486,0.0001614694,0.0004082533,0.000189729,0.0003527941,0.0002203684,0.0001767052,0.0006656528,0.000509059],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001693021,"about_ca_system_score_gemma":0.0002031955,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005508305,"about_ca_topic_score_gemma":0.0003966136,"domain_scores_codex":[0.999831,0.00004198906,0.00001841165,0.00003708802,0.00004592758,0.00002563911],"domain_scores_gemma":[0.9995919,0.0001638295,0.0001161743,0.00004555076,0.00002557224,0.00005694926],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003725119,0.00004477038,0.001079669,0.00003080867,0.00002618139,0.0002073756,0.0000322837,0.0001936605,0.9958156,0.0001336175,0.00001888489,0.002044552],"study_design_scores_gemma":[0.00004820162,0.0004390567,0.012046,0.000009389977,0.00007497356,0.001788537,0.00004340449,0.001465875,0.9825164,0.00008273355,0.001471599,0.00001386033],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996396,0.0002239457,0.002773975,0.00003725028,0.00001278211,0.00001625494,0.0001081286,0.00001345481,0.0004181874],"genre_scores_gemma":[0.9967983,0.0001629963,0.002286781,0.00003280133,0.000005653275,0.00001456897,0.0003690148,0.00001738036,0.0003123822],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.000967438,"threshold_uncertainty_score":0.003236413,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07188290298923179,"score_gpt":0.2787769086491942,"score_spread":0.2068940056599624,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}