{"id":"W2091161919","doi":"10.1073/pnas.1311029111","title":"Sequential breakdown of 3-phosphorylated phosphoinositides is essential for the completion of macropinocytosis","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":true,"ca_institutions":"St. Michael's Hospital","funders":"National Institute of Allergy and Infectious Diseases; National Institute of General Medical Sciences","keywords":"Pinocytosis; Endocytosis; Cell biology; Endocytic cycle; Pi; Biology; Phosphatase; Phosphorylation; Biochemistry; Cell","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000134147,0.0005382536,0.0003523079,0.0002184401,0.0002839242,0.0005686268,0.0003021827,0.0003833974,0.0008376313],"category_scores_gemma":[0.0002375238,0.0002676045,0.0003919138,0.0001139126,0.0002848439,0.0003588615,0.000468117,0.0006864258,0.0008857421],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005722782,"about_ca_system_score_gemma":0.0004005488,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001158182,"about_ca_topic_score_gemma":0.001288503,"domain_scores_codex":[0.9998046,0.0000163398,0.00002634931,0.00005354109,0.00005752157,0.0000416457],"domain_scores_gemma":[0.9997267,0.00003528768,0.00008556759,0.0000322084,0.0000297846,0.00009039626],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009039309,0.00001187324,0.0001902108,0.00003177753,0.0000027403,0.00008155393,0.000004686668,0.00007265922,0.9984292,0.0001156155,0.00004508382,0.0009242315],"study_design_scores_gemma":[0.00001313293,0.00006505305,0.01044267,0.000008320431,0.000009633219,0.000288834,0.00001625867,0.001351792,0.9852046,0.0001279582,0.002462032,0.000009632889],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9842243,0.003546458,0.007700817,0.000204174,0.00007953413,0.00005094841,0.001035292,0.0004640152,0.002694473],"genre_scores_gemma":[0.9932018,0.0009318448,0.00318695,0.00005762794,0.00001208054,0.00004115111,0.0007971444,0.00005383073,0.00171765],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001158182,"threshold_uncertainty_score":0.004152179,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02465937614849117,"score_gpt":0.2804514302188999,"score_spread":0.2557920540704087,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}