{"id":"W2091181651","doi":"10.1042/bj20030774","title":"Stable dimeric assembly of the second membrane-spanning domain of CFTR (cystic fibrosis transmembrane conductance regulator) reconstitutes a chloride-selective pore","year":2003,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cystic Fibrosis Research Advances","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; University of Toronto","funders":"Hospital for Sick Children; University of Toronto","keywords":"Chemistry; Cystic fibrosis transmembrane conductance regulator; Chloride channel; Chloride; Biophysics; Membrane; Transmembrane protein; Cysteine; Membrane potential; Biochemistry; Biology; Organic chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006655082,0.0002564832,0.0007099941,0.0001406549,0.0001454933,0.00002615371,0.0003030612,0.0001501502,0.0004538955],"category_scores_gemma":[0.001600792,0.0001782203,0.0003169415,0.0007817656,0.0006756452,0.0001946893,0.00003637957,0.0007006003,0.000002356015],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001688547,"about_ca_system_score_gemma":0.0007613838,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000008459549,"about_ca_topic_score_gemma":0.000003660128,"domain_scores_codex":[0.997384,0.0001678161,0.0007949189,0.0003257064,0.0007938505,0.0005337156],"domain_scores_gemma":[0.9978947,0.0004845277,0.000458134,0.0003887846,0.0004599261,0.0003139314],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008801417,0.0001471176,0.001022287,0.0004533835,0.0001850726,0.00002052137,0.0001841152,0.00002094693,0.9954674,0.0002878192,0.00118053,0.0001506753],"study_design_scores_gemma":[0.001872836,0.0002894334,0.001631259,0.0008802425,0.0000996728,0.001256597,0.0003009317,0.00002767568,0.989028,0.0008918009,0.003546985,0.0001745142],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.992753,0.003845248,0.000676019,0.000289594,0.0002710953,0.000388416,0.0000455477,0.0000163107,0.001714716],"genre_scores_gemma":[0.9857454,0.00008750588,0.01345804,0.00005326081,0.000108211,0.00001142963,0.000006339229,0.00003080521,0.000498986],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01278202,"threshold_uncertainty_score":0.7267614,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01456367281284786,"score_gpt":0.2695422341372999,"score_spread":0.2549785613244521,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}