{"id":"W2091203739","doi":"10.1101/gad.1145603","title":"Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis","year":2003,"lang":"en","type":"article","venue":"Genes & Development","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; Bone morphogenetic protein; Cell biology; Mesoderm; SMAD; BMPR2; Signal transduction; Decapentaplegic; R-SMAD; Chordin; Epiblast; Smad2 Protein; Gastrulation; Embryonic stem cell; Genetics; Embryogenesis; Mutant; Embryo; Gene; Endoglin; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001690341,0.0001876106,0.0001352335,0.00005441496,0.0002642346,0.00004312086,0.0001050722,0.0001031744,0.00001866714],"category_scores_gemma":[0.00004271049,0.0001962872,0.0000558301,0.00004988865,0.00002386826,0.000009914625,0.00006416538,0.00002182444,0.000006603131],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003647646,"about_ca_system_score_gemma":0.0001426787,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001127467,"about_ca_topic_score_gemma":0.000006040874,"domain_scores_codex":[0.9988937,0.00003070734,0.000301414,0.0003473333,0.0001342037,0.0002925904],"domain_scores_gemma":[0.9995058,0.00001084737,0.00009546879,0.0001987238,0.00008665289,0.0001025054],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000597984,0.00003234248,0.001335029,0.0001112446,0.00007926146,0.000001139262,0.0003160252,0.0001466246,0.994042,0.00001674786,0.0002323056,0.003627427],"study_design_scores_gemma":[0.0005770804,0.00002613776,0.0008431614,0.00001913162,0.00002292106,0.00001057059,0.000130605,0.00002139874,0.965075,0.00001958555,0.03298353,0.0002709031],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884415,0.003262969,0.007776028,0.00002343497,0.00007071234,0.0003245406,0.00001196852,0.00002669135,0.00006214229],"genre_scores_gemma":[0.9721566,0.0001604688,0.02562619,0.0002024595,0.0000692502,0.0001949852,0.0001339748,0.0000403151,0.001415786],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03275122,"threshold_uncertainty_score":0.8004358,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466110098978635,"score_gpt":0.2354255130517031,"score_spread":0.2207644120619167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}