{"id":"W2091203739","doi":"10.1101/gad.1145603","title":"Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis","year":2003,"lang":"en","type":"article","venue":"Genes & Development","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":102,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital; University of Toronto","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; National Institutes of Health; Howard Hughes Medical Institute","keywords":"Biology; Bone morphogenetic protein; Cell biology; Mesoderm; SMAD; BMPR2; Signal transduction; Decapentaplegic; R-SMAD; Chordin; Epiblast; Smad2 Protein; Gastrulation; Embryonic stem cell; Genetics; Embryogenesis; Mutant; Embryo; Gene; Endoglin; Stem cell","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001198588,0.0004990972,0.0001985494,0.0002937843,0.0002454577,0.0005098974,0.0002754535,0.0002623866,0.001635056],"category_scores_gemma":[0.0001667162,0.0002990895,0.0002487893,0.0001375428,0.0003046133,0.0002085172,0.0003891783,0.00045887,0.0009807878],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003182237,"about_ca_system_score_gemma":0.0002507721,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000524981,"about_ca_topic_score_gemma":0.0008107369,"domain_scores_codex":[0.9998046,0.00001885681,0.00002489168,0.00004204509,0.00006508041,0.00004459541],"domain_scores_gemma":[0.9997258,0.00002245635,0.0001035252,0.00002636694,0.00002498258,0.00009679171],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005649136,0.000005758559,0.0003550687,0.00001757934,0.000002512868,0.0001450288,0.000008232181,0.00003126764,0.9986134,0.0001247808,0.00002051079,0.0006193926],"study_design_scores_gemma":[0.0000118676,0.00005186641,0.01272673,0.000009878102,0.00001840402,0.0007188573,0.00002669945,0.0004853632,0.9823883,0.00005236626,0.003504622,0.000005170789],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990073,0.001565793,0.004484962,0.00008378265,0.00003218225,0.0000171046,0.0007280128,0.0001882799,0.002826861],"genre_scores_gemma":[0.9908628,0.0006980841,0.001694566,0.00004560166,0.00001442836,0.00002589036,0.001809984,0.00008556592,0.004763016],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001635056,"threshold_uncertainty_score":0.005469799,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466110098978635,"score_gpt":0.2354255130517031,"score_spread":0.2207644120619167,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}