{"id":"W2091214983","doi":"10.1038/mt.2013.161","title":"Toward Position-independent Retroviral Vector Expression in Pluripotent Stem Cells","year":2013,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Gene silencing; DNA methylation; CTCF; Epigenetics; Retrovirus; Genetics; Chromatin; Molecular biology; Viral vector; Transgene; Gene; Gene expression; Enhancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0009959048,0.0003986026,0.0003248543,0.0009108655,0.0002631246,0.001154255,0.0006597464,0.0006202994,0.002148526],"category_scores_gemma":[0.0006631962,0.000445792,0.000423948,0.0009032011,0.0004880704,0.0007995771,0.0007708347,0.002330422,0.00249804],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004939834,"about_ca_system_score_gemma":0.0004842473,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000333549,"about_ca_topic_score_gemma":0.0006617908,"domain_scores_codex":[0.9992232,0.0001313141,0.00007906058,0.00009034686,0.000444093,0.00003193109],"domain_scores_gemma":[0.9997316,0.00007549471,0.00004363523,0.00003897937,0.00009218929,0.00001810564],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000107551,0.00007847736,0.0004538671,0.001375069,0.00003404682,0.0003725016,0.0003301573,0.0007282365,0.8101764,0.02497854,0.003993549,0.1573717],"study_design_scores_gemma":[0.00003860696,0.0004979675,0.0009155592,0.0002759743,0.0001047404,0.001673773,0.0001210508,0.003153624,0.7064825,0.0093605,0.2773269,0.00004882695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"methods","genre_gemma":"empirical","genre_scores_codex":[0.08311523,0.08528669,0.7843124,0.006395506,0.003269787,0.0008163287,0.001363561,0.002072705,0.03336781],"genre_scores_gemma":[0.3069581,0.1938284,0.434899,0.00392397,0.001130154,0.0007489435,0.004512819,0.0008942193,0.05310443],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.002148526,"threshold_uncertainty_score":0.007187605,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009547279792562782,"score_gpt":0.2446785683264336,"score_spread":0.2351312885338708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}