{"id":"W2091214983","doi":"10.1038/mt.2013.161","title":"Toward Position-independent Retroviral Vector Expression in Pluripotent Stem Cells","year":2013,"lang":"en","type":"letter","venue":"Molecular Therapy","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Biology; Gene silencing; DNA methylation; CTCF; Epigenetics; Retrovirus; Genetics; Chromatin; Molecular biology; Viral vector; Transgene; Gene; Gene expression; Enhancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.00009898507,0.0004634174,0.0003350234,0.0001283811,0.00003487879,0.00006975763,0.0004104452,0.0009605237,0.00008019149],"category_scores_gemma":[0.000002956547,0.0004446119,0.0002632829,0.00008021243,0.00003230182,0.000003652094,0.0001123465,0.0007185531,0.00005735027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006253564,"about_ca_system_score_gemma":0.00005773926,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003285724,"about_ca_topic_score_gemma":0.000001955395,"domain_scores_codex":[0.9979273,0.0001309852,0.0003488311,0.0007127383,0.0003738742,0.0005062484],"domain_scores_gemma":[0.9990547,0.000007511988,0.0001050718,0.0006965965,0.00006069151,0.00007542223],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003228433,0.0000324837,0.00001513904,0.00004453749,0.00005797397,0.0002771448,0.00004815718,0.0003343197,0.9123709,0.000001042853,0.08536758,0.001418427],"study_design_scores_gemma":[0.0006414262,0.0002273914,0.00007388326,0.00005820525,0.000008605659,0.00001893969,0.00001101249,0.00003459315,0.7667532,0.00001497825,0.2317339,0.000423917],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8291304,0.02831217,0.05377756,0.08157243,0.002978027,0.003106403,0.0001619383,0.0001406538,0.0008204477],"genre_scores_gemma":[0.7547408,0.002744178,0.001716166,0.2310722,0.003362571,0.000483542,0.001418126,0.000440498,0.004021938],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1494997,"threshold_uncertainty_score":0.9998006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009547279792562782,"score_gpt":0.2446785683264336,"score_spread":0.2351312885338708,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}