{"id":"W2091260658","doi":"10.1021/mp400024d","title":"Polyamine Transport by the Polyspecific Organic Cation Transporters OCT1, OCT2, and OCT3","year":2013,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute","keywords":"Organic cation transport proteins; Spermidine; Chemistry; Polyamine; Spermine; Transporter; Putrescine; Biochemistry; Solute carrier family; Mediated transport; Biophysics; Enzyme; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001123349,0.0002236507,0.0001410545,0.00003318319,0.0001439766,0.00003578741,0.0002745602,0.0001095725,0.00009612359],"category_scores_gemma":[0.00000730072,0.000184321,0.00007688456,0.0001731494,0.0001667703,0.000009111789,0.00003103768,0.0001461575,0.00003037312],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000008614707,"about_ca_system_score_gemma":0.00003773436,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005603744,"about_ca_topic_score_gemma":0.000009804189,"domain_scores_codex":[0.9988518,0.00004731145,0.0002529559,0.0003674949,0.0001672251,0.0003132375],"domain_scores_gemma":[0.9992542,0.000008174075,0.00007394783,0.0004409021,0.00006235717,0.0001603953],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000008317349,0.00006103406,0.0006476855,0.000009510006,0.00005112375,0.000001527118,0.00007622245,0.000004250548,0.9897684,0.0001156623,0.002233729,0.007022514],"study_design_scores_gemma":[0.0006081803,0.00003291751,0.004268219,0.000002778446,0.000113737,0.00002856185,0.00008868025,0.000122455,0.837235,0.00006312368,0.1571875,0.0002487943],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9750087,0.006513236,0.01502667,0.002188919,0.00009405295,0.0005508983,0.00008199851,0.00002898424,0.0005065829],"genre_scores_gemma":[0.9949495,0.001044707,0.0002391687,0.00206393,0.0001082683,0.0000985645,0.0004513999,0.00004384082,0.001000672],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1549538,"threshold_uncertainty_score":0.7516393,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007464953593271087,"score_gpt":0.2438263313315328,"score_spread":0.2363613777382617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}