{"id":"W2091260658","doi":"10.1021/mp400024d","title":"Polyamine Transport by the Polyspecific Organic Cation Transporters OCT1, OCT2, and OCT3","year":2013,"lang":"en","type":"article","venue":"Molecular Pharmaceutics","topic":"Polyamine Metabolism and Applications","field":"Biochemistry, Genetics and Molecular Biology","cited_by":87,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute on Minority Health and Health Disparities; National Center for Research Resources; National Institute of Neurological Disorders and Stroke; National Heart, Lung, and Blood Institute","keywords":"Organic cation transport proteins; Spermidine; Chemistry; Polyamine; Spermine; Transporter; Putrescine; Biochemistry; Solute carrier family; Mediated transport; Biophysics; Enzyme; Biology; Membrane","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001345516,0.0003225841,0.0001940867,0.0001381027,0.0002076293,0.0006798198,0.0001758009,0.0003789071,0.001215501],"category_scores_gemma":[0.0001951148,0.0001868103,0.0004155656,0.000195654,0.0001630251,0.000537861,0.0002187769,0.000458792,0.0005598481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006441689,"about_ca_system_score_gemma":0.0004230068,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.003367837,"about_ca_topic_score_gemma":0.00470606,"domain_scores_codex":[0.9998149,0.00002035715,0.00001807006,0.00004994082,0.00005575867,0.0000408764],"domain_scores_gemma":[0.9998289,0.00001919653,0.00005117722,0.00001148507,0.00005216973,0.00003706811],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000112954,0.000006132627,0.0008025548,0.0000603369,0.00001237194,0.00005945582,0.00001906399,0.0001175475,0.9965308,0.0003104016,0.00009751473,0.001870886],"study_design_scores_gemma":[0.00003016291,0.0001568409,0.02179889,0.00002101285,0.00005673438,0.0007870665,0.0001300904,0.004303529,0.9581515,0.0001732658,0.0143646,0.00002623763],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9816575,0.00461802,0.007442751,0.000226431,0.00007017676,0.00003590687,0.001096834,0.00009672919,0.004755521],"genre_scores_gemma":[0.9771238,0.003478229,0.006083884,0.0003160423,0.0000226707,0.00004525977,0.001946519,0.00008714454,0.01089635],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003367837,"threshold_uncertainty_score":0.006696463,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007464953593271087,"score_gpt":0.2438263313315328,"score_spread":0.2363613777382617,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}