{"id":"W2091297863","doi":"10.1016/j.bbapap.2007.08.017","title":"Too much of a good thing: The role of protein kinase CK2 in tumorigenesis and prospects for therapeutic inhibition of CK2","year":2007,"lang":"en","type":"review","venue":"Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics","topic":"Protein Kinase Regulation and GTPase Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":308,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Carcinogenesis; Oncogene; Suppressor; Kinase; Cancer research; Biology; Protein kinase A; Serine; Malignant transformation; Cell biology; Threonine; Phosphorylation; Apoptosis; Cell cycle; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0008731628,0.0005400449,0.001187085,0.0002267713,0.00009852339,0.00003594516,0.0002732057,0.0005203622,0.000001677104],"category_scores_gemma":[0.00008550749,0.0004034505,0.0003815759,0.0003711988,0.0003710854,0.00001795651,0.0002140268,0.0002750752,1.808351e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002864588,"about_ca_system_score_gemma":0.0003852744,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005129539,"about_ca_topic_score_gemma":0.00001463363,"domain_scores_codex":[0.9974211,0.0002412397,0.001067638,0.0006599448,0.000258963,0.0003511551],"domain_scores_gemma":[0.997812,0.00005679716,0.001280288,0.0005724131,0.0001946451,0.00008380417],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002924083,0.0002614064,0.000002389724,0.008194608,0.0001537116,8.450814e-7,0.0001599095,6.332369e-7,0.9420037,0.002317108,0.000002289413,0.04661095],"study_design_scores_gemma":[0.000729926,0.0008416752,0.00002435255,0.003563512,0.0002148186,0.000009463445,0.00006348937,0.00003770592,0.9821692,0.001830541,0.01008706,0.0004283],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"review","genre_gemma":"empirical","genre_scores_codex":[0.4860261,0.5032657,0.0003946506,0.0000923281,0.00002356207,0.009813194,0.0003261903,0.00001158377,0.00004669031],"genre_scores_gemma":[0.6252176,0.3673754,0.005111642,0.00003339051,0.0001769524,0.00165645,0.0002798614,0.0001105372,0.00003815884],"genre_candidate":"empirical","genre_consensus":null,"teacher_disagreement_score":0.1391915,"threshold_uncertainty_score":0.9998417,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0226541872754896,"score_gpt":0.2890745718800727,"score_spread":0.2664203846045832,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}