{"id":"W2091326791","doi":"10.1136/jnnp-2011-301993.20","title":"1142 Mexiletine is an effective treatment in non-dystrophic myotonia","year":2012,"lang":"en","type":"article","venue":"Journal of Neurology Neurosurgery & Psychiatry","topic":"Genetic Neurodegenerative Diseases","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"London Health Sciences Centre","funders":"","keywords":"Mexiletine; Medicine; Myotonia; Placebo; Crossover study; Weakness; Anesthesia; Muscle stiffness; Myotonia congenita; Internal medicine; Physical therapy; Cardiology; Myotonic dystrophy; Surgery; Stiffness","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004933691,0.0003788955,0.001358235,0.000453016,0.0002941501,0.0002256402,0.0003468362,0.0008486394,0.005843744],"category_scores_gemma":[0.0005480136,0.000170147,0.0005141981,0.0002563044,0.000255909,0.0002004677,0.0002063483,0.0006707602,0.0006503369],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001483942,"about_ca_system_score_gemma":0.0001542298,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003643364,"about_ca_topic_score_gemma":0.0009683948,"domain_scores_codex":[0.9997992,0.00009662128,0.00002478975,0.0000205757,0.00003886531,0.00001996193],"domain_scores_gemma":[0.9997905,0.00009925776,0.0000409304,0.000009603054,0.0000139631,0.00004579954],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.2189429,0.01307318,0.006256253,0.01214552,0.00154201,0.003817382,0.0002287244,0.0003814418,0.1178998,0.0003953423,0.01011179,0.6152057],"study_design_scores_gemma":[0.349452,0.3271863,0.2310152,0.001481902,0.001942403,0.006553025,0.000230703,0.0009076762,0.0228273,0.0004427256,0.05784115,0.0001197186],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8301997,0.1514622,0.0009015022,0.001797249,0.0009465596,0.0009962941,0.0006913571,0.0001489426,0.01285614],"genre_scores_gemma":[0.9387542,0.04872345,0.001605391,0.001979467,0.001146336,0.0006368429,0.0008919319,0.00002130362,0.006241055],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005843744,"threshold_uncertainty_score":0.01954919,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01993982047540827,"score_gpt":0.2821670015292807,"score_spread":0.2622271810538724,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}